Static and dynamic light scattering of healthy and malaria-parasite blood cells
Author(s)Suresh, Subra; Park, YongKeun; Diez Silva, Monica; Fu, Dan; Barman, Ishan; Feld, Michael S.; Popescu, Gabriel; Choi, Wonshik; ... Show more Show less
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We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.
DepartmentMassachusetts Institute of Technology. Department of Materials Science and Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering; Massachusetts Institute of Technology. School of Engineering; Massachusetts Institute of Technology. Spectroscopy Laboratory
Journal of Biomedical Optics
Society of Photo-optical Instrumentation Engineers
Park, YongKeun et al. “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells.” Journal of Biomedical Optics 15.2 (2010): 020506-3.©2010 Society of Photo-Optical Instrumentation Engineers.
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