Show simple item record

dc.contributor.authorZhou, Chao
dc.contributor.authorWong, Yihong
dc.contributor.authorAguirre, Aaron Dominic
dc.contributor.authorTsai, Tsung-Han
dc.contributor.authorCohen, David W.
dc.contributor.authorConnolly, James L.
dc.contributor.authorFujimoto, James G.
dc.date.accessioned2010-09-17T17:28:04Z
dc.date.available2010-09-17T17:28:04Z
dc.date.issued2010-02
dc.date.submitted2010-01
dc.identifier.issn0277-786X
dc.identifier.urihttp://hdl.handle.net/1721.1/58587
dc.description.abstractWe evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. Thirty four thyroid gland specimens were imaged from 17 patients, covering a spectrum of pathology, ranging from normal thyroid to neoplasia and benign disease. The integrated OCT and OCM imaging system allows seamlessly switching between low and high magnifications, in a way similar to traditional microscopy. Good correspondence was observed between optical images and histological sections. The results provide a basis for interpretation of future OCT and OCM images of the thyroid tissues and suggest the possibility of future in vivo evaluation of thyroid pathology.en_US
dc.description.sponsorshipNational Institutes of Health (U.S) ( R01-CA75289-13 )en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (contract FA9550-07-1-0014)en_US
dc.description.sponsorshipUnited States. Dept. of Defense.Medical Free Electron Laser Program (contract FA9550-07-1-0101)en_US
dc.description.sponsorshipMIT/CIMIT Medical Engineering Fellowshipen_US
dc.language.isoen_US
dc.publisherSPIEen_US
dc.relation.isversionofhttp://dx.doi.org/10.1117/12.843616en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSPIEen_US
dc.subjectOptical coherence tomography (OCT)en_US
dc.subjectOptical coherence microscopy (OCM)en_US
dc.subjectThyroiden_US
dc.subjectPathologyen_US
dc.subjectCanceren_US
dc.titleMultiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM)en_US
dc.typeArticleen_US
dc.identifier.citationZhou, Chao et al. “Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM).” Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV. Ed. Joseph A. Izatt, James G. Fujimoto, & Valery V. Tuchin. San Francisco, California, USA: SPIE, 2010. 755409-8. ©2010 COPYRIGHT SPIE--The International Society for Optical Engineeringen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.approverFujimoto, James G.
dc.contributor.mitauthorZhou, Chao
dc.contributor.mitauthorAguirre, Aaron Dominic
dc.contributor.mitauthorTsai, Tsung-Han
dc.contributor.mitauthorFujimoto, James G.
dc.relation.journalProceedings of SPIE--the International Society for Optical Engineering; v.7554en_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsZhou, Chao; Wang, Yihong; Aguirre, Aaron D.; Tsai, Tsung-Han; Cohen, David W.; Connolly, James L.; Fujimoto, James G.en
dc.identifier.orcidhttps://orcid.org/0000-0002-0828-4357
mit.licensePUBLISHER_POLICYen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record