dc.contributor.author | Zhou, Chao | |
dc.contributor.author | Wong, Yihong | |
dc.contributor.author | Aguirre, Aaron Dominic | |
dc.contributor.author | Tsai, Tsung-Han | |
dc.contributor.author | Cohen, David W. | |
dc.contributor.author | Connolly, James L. | |
dc.contributor.author | Fujimoto, James G. | |
dc.date.accessioned | 2010-09-17T17:28:04Z | |
dc.date.available | 2010-09-17T17:28:04Z | |
dc.date.issued | 2010-02 | |
dc.date.submitted | 2010-01 | |
dc.identifier.issn | 0277-786X | |
dc.identifier.uri | http://hdl.handle.net/1721.1/58587 | |
dc.description.abstract | We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. Thirty four thyroid gland specimens were imaged from 17 patients, covering a spectrum of pathology, ranging from normal thyroid to neoplasia and benign disease. The integrated OCT and OCM imaging system allows seamlessly switching between low and high magnifications, in a way similar to traditional microscopy. Good correspondence was observed between optical images and histological sections. The results provide a basis for interpretation of future OCT and OCM images of the thyroid tissues and suggest the possibility of future in vivo evaluation of thyroid pathology. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S) ( R01-CA75289-13 ) | en_US |
dc.description.sponsorship | United States. Air Force Office of Scientific Research (contract FA9550-07-1-0014) | en_US |
dc.description.sponsorship | United States. Dept. of Defense.Medical Free Electron Laser Program (contract FA9550-07-1-0101) | en_US |
dc.description.sponsorship | MIT/CIMIT Medical Engineering Fellowship | en_US |
dc.language.iso | en_US | |
dc.publisher | SPIE | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1117/12.843616 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | SPIE | en_US |
dc.subject | Optical coherence tomography (OCT) | en_US |
dc.subject | Optical coherence microscopy (OCM) | en_US |
dc.subject | Thyroid | en_US |
dc.subject | Pathology | en_US |
dc.subject | Cancer | en_US |
dc.title | Multiscale imaging of human thyroid pathologies using integrated Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Zhou, Chao et al. “Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM).” Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV. Ed. Joseph A. Izatt, James G. Fujimoto, & Valery V. Tuchin. San Francisco, California, USA: SPIE, 2010. 755409-8. ©2010 COPYRIGHT SPIE--The International Society for Optical Engineering | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Research Laboratory of Electronics | en_US |
dc.contributor.approver | Fujimoto, James G. | |
dc.contributor.mitauthor | Zhou, Chao | |
dc.contributor.mitauthor | Aguirre, Aaron Dominic | |
dc.contributor.mitauthor | Tsai, Tsung-Han | |
dc.contributor.mitauthor | Fujimoto, James G. | |
dc.relation.journal | Proceedings of SPIE--the International Society for Optical Engineering; v.7554 | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Zhou, Chao; Wang, Yihong; Aguirre, Aaron D.; Tsai, Tsung-Han; Cohen, David W.; Connolly, James L.; Fujimoto, James G. | en |
dc.identifier.orcid | https://orcid.org/0000-0002-0828-4357 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |