dc.contributor.author | Qin, Zhao | |
dc.contributor.author | Buehler, Markus J | |
dc.date.accessioned | 2010-09-28T15:37:32Z | |
dc.date.available | 2010-09-28T15:37:32Z | |
dc.date.issued | 2010-05 | |
dc.date.submitted | 2009-09 | |
dc.identifier.issn | 0031-9007 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/58734 | |
dc.description.abstract | The alpha-helix to beta-sheet transition (α-β transition) is a universal deformation mechanism in alpha-helix rich protein materials such as wool, hair, hoof, and cellular proteins. Through a combination of molecular and theoretical modeling, we examine the behavior of alpha-helical coiled-coil proteins with varying lengths under stretch. We find that the occurrence of the α-β transition is controlled by the length of constituting alpha-helical proteins. In the asymptotic limit, short proteins with less than 26 amino acids or 3.8 nm length reveal interprotein sliding, whereas proteins with greater lengths feature an α-β transition, leading to a significant increase in the protein’s stiffness, strength, and energy dissipation capacity at large deformation. Our study elucidates the fundamental physics of this mechanism and explains why the α-β transition typically occurs in protein filaments with long alpha-helical domains. | en_US |
dc.description.sponsorship | United States. Air Force Office of Scientific Research (Grant No. FA9550081-0321) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Physical Society | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1103/PhysRevLett.104.198304 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | APS | en_US |
dc.title | Molecular Dynamics Simulation of the alpha-Helix to beta-Sheet Transition in Coiled Protein Filaments: Evidence for a Critical Filament Length Scale | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Qin Zhao, and Markus J. Buehler. "Molecular Dynamics Simulation of the α-Helix to β-Sheet Transition in Coiled Protein Filaments: Evidence for a Critical Filament Length Scale." Physical Review Letters 104.19 (2010): 198304. © 2010 The American Physical Society | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Laboratory for Atomistic and Molecular Mechanics | en_US |
dc.contributor.approver | Buehler, Markus J. | |
dc.contributor.mitauthor | Buehler, Markus J. | |
dc.contributor.mitauthor | Qin, Zhao | |
dc.relation.journal | Physical Review Letters | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Qin, Zhao; Buehler, Markus J. | en |
dc.identifier.orcid | https://orcid.org/0000-0002-4173-9659 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |