A wireless-compatible CMOS-based celluar sensor
Author(s)Matsudaira, Paul T.; Anwar, Mekhail
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Biosensors have a need to accurately detect and quantify a biological target within a complex medium, such as serum. Cells are uniquely qualified to accomplish this, but cannot communicate with the outside world. We demonstrate a synergistic fusion between a genetically engineered cell line and a wireless-compatible CMOS sensor leveraging the cells innate ability to specifically bind, amplify and transduce the signal with electronics that are capable transforming this cellular signal into an electronic one. We demonstrate the detection of TNF-alpha (TNFalpha) within serum without washing. Since cells are real-time transducers of binding events, real-time monitoring of biological agents and reactions are possible.
The title as published reads "celluar sensor" but should be "cellular sensor."
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Whitehead Institute for Biomedical Research
Solid-State Sensors, Actuators and Microsystems Conference. TRANSDUCERS
Institute of Electrical and Electronics Engineers
M. Anwar and P. Matsudaira, “Wireless-compatible CMOS-based celluar sensor,” in Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International, 2009, 936-938, 10.1109/SENSOR.© 2009, IEEE
Final published version
INSPEC Accession Number: 10916883
CMOS, Imaging, Array, Cell-based, Biosensor, Luciferase