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A wireless-compatible CMOS-based celluar sensor

Author(s)
Matsudaira, Paul T.; Anwar, Mekhail
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.

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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
Biosensors have a need to accurately detect and quantify a biological target within a complex medium, such as serum. Cells are uniquely qualified to accomplish this, but cannot communicate with the outside world. We demonstrate a synergistic fusion between a genetically engineered cell line and a wireless-compatible CMOS sensor leveraging the cells innate ability to specifically bind, amplify and transduce the signal with electronics that are capable transforming this cellular signal into an electronic one. We demonstrate the detection of TNF-alpha (TNFalpha) within serum without washing. Since cells are real-time transducers of binding events, real-time monitoring of biological agents and reactions are possible.
Description
The title as published reads "celluar sensor" but should be "cellular sensor."
Date issued
2009-06
URI
http://hdl.handle.net/1721.1/58840
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Whitehead Institute for Biomedical Research
Journal
Solid-State Sensors, Actuators and Microsystems Conference. TRANSDUCERS
Publisher
Institute of Electrical and Electronics Engineers
Citation
M. Anwar and P. Matsudaira, “Wireless-compatible CMOS-based celluar sensor,” in Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International, 2009, 936-938, 10.1109/SENSOR.© 2009, IEEE
Version: Final published version
Other identifiers
INSPEC Accession Number: 10916883
E-ISBN: 978-1-4244-4193-8
ISBN
978-1-4244-4190-7
Keywords
CMOS, Imaging, Array, Cell-based, Biosensor, Luciferase

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