Multimodal functional imaging using fMRI-Informed regional EEG/MEG estimation
Author(s)Ou, Wanmei; Nummenmaa, Aapo; Golland, Polina; Hamalainen, Matti S.
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We propose a novel method, fMRI-informed regional estimation (FIRE), which utilizes information from fMRI in E/MEG source reconstruction. FIRE takes advantage of the spatial alignment between the neural and the vascular activities, while allowing for substantial differences in their dynamics. Furthermore, with the regional approach, FIRE can be efficiently applied to a dense grid of sources. Inspection of our optimization procedure reveals that FIRE is related to the re-weighted minimum-norm algorithms, the difference being that the weights in the proposed approach are computed from both the current estimates and fMRI data. Analysis of both simulated and human fMRI-MEG data shows that FIRE reduces the ambiguities in source localization present in the minimum-norm estimates. Comparisons with several joint fMRI-E/MEG algorithms demonstrate robustness of FIRE in the presence of sources silent to either fMRI or E/MEG measurements.
DepartmentMassachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009
Institute of Electrical and Electronics Engineers
Wanmei Ou, Nummenmaa, A., Golland, P., and Hamalainen, M.S. (2009). Multimodal functional imaging using fMRI-Informed regional EEG/MEG source estimation. Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009 (Piscataway, N.J.: IEEE): 1926-1929. © 2009 IEEE
Final published version
INSPEC Accession Number: 10992123