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A mouse plasma peptide atlas as a resource for disease proteomics

dc.contributor.authorZhang, Qing
dc.contributor.authorMenon, Rajasree
dc.contributor.authorWang, Hong
dc.contributor.authorBardeesy, Nabeel
dc.contributor.authorDinulescu, Daniela M.
dc.contributor.authorKucherlapati, Raju
dc.contributor.authorPoliti, Katerina
dc.contributor.authorAebersold, Ruedi
dc.contributor.authorDeutsch, Eric W.
dc.contributor.authorPitteri, Sharon J.
dc.contributor.authorFaca, Vitor M.
dc.contributor.authorNewcomb, Lisa F.
dc.contributor.authorDePinho, Ronald A.
dc.contributor.authorHung, Kenneth E.
dc.contributor.authorOmenn, Gilbert S.
dc.contributor.authorStates, David J.
dc.contributor.authorHanash, Samir M.
dc.contributor.authorJacks, Tyler E
dc.date.accessioned2010-10-14T12:22:33Z
dc.date.available2010-10-14T12:22:33Z
dc.date.issued2008-06
dc.date.submitted2008-01
dc.identifier.issn1474-760X
dc.identifier.issn1465-6914
dc.identifier.urihttp://hdl.handle.net/1721.1/59306
dc.description.abstractWe present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.en_US
dc.description.sponsorshipNational Heart, Lung, and Blood Institute (contract no. N01-HV-28179)en_US
dc.description.sponsorshipNational Cancer Institute (U.S.)en_US
dc.publisherBioMed Central Ltden_US
dc.relation.isversionofhttp://dx.doi.org/10.1186/gb-2008-9-6-r93en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.sourceBioMed Central Ltden_US
dc.subjectAlternative splicingen_US
dc.subjectAnimalsen_US
dc.subjectDatabases, proteinen_US
dc.subjectHumansen_US
dc.subjectMiceen_US
dc.subjectPeptides, analysisen_US
dc.subjectPlasma, chemistryen_US
dc.subjectProtein isoformsen_US
dc.subjectProteomicsen_US
dc.subjectTandem mass spectrometryen_US
dc.titleA mouse plasma peptide atlas as a resource for disease proteomicsen_US
dc.typeArticleen_US
dc.identifier.citationZhang, Qing et al. (2008). A mouse plasma peptide atlas as a resource for disease proteomics. Genome biology 9:R93/1-10.en_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorJacks, Tyler E.
dc.relation.journalGenome Biologyen_US
dc.eprint.versionFinal published versionen_US
dc.identifier.pmid18522751
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2010-09-03T16:07:07Z
dc.language.rfc3066en
dc.rights.holderZhang et al.; licensee BioMed Central Ltd.
dspace.orderedauthorsZhang, Qing; Menon, Rajasree; Deutsch, Eric W; Pitteri, Sharon J; Faca, Vitor M; Wang, Hong; Newcomb, Lisa F; DePinho, Ronald A; Bardeesy, Nabeel; Dinulescu, Daniela; Hung, Kenneth E; Kucherlapati, Raju; Jacks, Tyler; Politi, Katerina; Aebersold, Ruedi; Omenn, Gilbert S; States, David J; Hanash, Samir Men
dc.identifier.orcidhttps://orcid.org/0000-0001-5785-8911
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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