The Boston retinal prosthesis a 15-channel hermetic wireless neural stimulator
Author(s)Wyatt, John L.; Cogan, Stuart F.; Theogarajan, Luke S.; Chen, Jinghua; Kelly, Shawn K.; Shire, Douglas B.; Doyle, Patrick S.; Gingerich, Marcus D.; Drohan, William A.; Rizzo, Joseph F.; ... Show more Show less
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A miniaturized, hermetically-encased, wirelessly-operated retinal prosthesis has been developed for pre-clinical studies in Yucatan minipig animal models. The prosthesis attaches conformally to the outside of the eye and drives a microfabricated thin-film polyimide stimulating electrode array with sputtered iridium oxide electrodes. This array is implanted in the subretinal space using a specially-designed ab externo surgical technique that uses the retina to hold the array in place while leaving the bulk of the prosthesis outside the eye. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete circuit components. Feedthroughs from the case connect to secondary power- and data-receiving coils. In addition, long-term in vitro pulse testing was performed on the electrodes to ensure that their lifetime would match that of the hermetic case. The final assembly was tested in vitro to verify wireless operation of the system in biological saline using a custom RF transmitter circuit and primary coils. Stimulation pulse strength, duration and frequency were programmed wirelessly using a custom graphical user interface. Operation of the retinal implant has been verified in vivo in two pigs for up to five and a half months by measuring stimulus artifact on the eye surface using a contact lens electrode.
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
2nd International Symposium on Applied Sciences in Biomedical and Communication Technologies, 2009. ISABEL 2009
Institute of Electrical and Electronics Engineers
Kelly, S.K. et al. “The Boston retinal prosthesis: A 15-channel hermetic wireless neural stimulator.” Applied Sciences in Biomedical and Communication Technologies, 2009. ISABEL 2009. 2nd International Symposium on. 2009. 1-6. ©2010 Institute of Electrical and Electronics Engineers.
Final published version
INSPEC Accession Number: 11057178
bioelectric potentials, biomedical electrodes, biomedical engineering, integrated circuit design, iridium, neuromuscular stimulation, telemetry