New insights into oxidative folding
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The oxidoreductase ERO1 (endoplasmic reticulum [ER] oxidoreductin 1) is thought to be crucial for disulfide bond formation in the ER. In this issue, Zito et al. (2010. J. Cell Biol. doi:10.1083/jcb.200911086) examine the division of labor between the two mammalian isoforms of ERO1 (ERO1-α and -β) in oxidative folding. Their analysis reveals a selective role for ERO1-β in insulin production and a surprisingly minor contribution for either ERO1 isoform on immunoglobulin folding and secretion.
Date issued
2010-03Department
Massachusetts Institute of Technology. Department of BiologyJournal
Journal of Cell Biology
Publisher
Rockefeller University Press
Citation
Sevier, Carolyn S. “New insights into oxidative folding.” The Journal of Cell Biology 188.6 (2010): 757 -758. Copyright © 2010 by The Rockefeller University Press
Version: Final published version
ISSN
1540-8140
0021-9525