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dc.contributor.authorMundra, Piyushkumar A.
dc.contributor.authorRajapakse, Jagath
dc.date.accessioned2011-04-08T15:12:53Z
dc.date.available2011-04-08T15:12:53Z
dc.date.issued2010-03
dc.date.submitted2009-10
dc.identifier.issn1536-1241
dc.identifier.otherINSPEC Accession Number: 11206252
dc.identifier.urihttp://hdl.handle.net/1721.1/62171
dc.description.abstractWe enhance the support vector machine recursive feature elimination (SVM-RFE) method for gene selection by incorporating a minimum-redundancy maximum-relevancy (MRMR) filter. The relevancy of a set of genes are measured by the mutual information among genes and class labels, and the redundancy is given by the mutual information among the genes. The method improved identification of cancer tissues from benign tissues on several benchmark datasets, as it takes into account the redundancy among the genes during their selection. The method selected a less number of genes compared to MRMR or SVM-RFE on most datasets. Gene ontology analyses revealed that the method selected genes that are relevant for distinguishing cancerous samples and have similar functional properties. The method provides a framework for combining filter methods and wrapper methods of gene selection, as illustrated with MRMR and SVM-RFE methods.en_US
dc.language.isoen_US
dc.publisherInstitute of Electrical and Electronics Engineersen_US
dc.relation.isversionofhttp://dx.doi.org/10.1109/tnb.2009.2035284en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceIEEEen_US
dc.titleSVM-RFE With MRMR Filter for Gene Selectionen_US
dc.typeArticleen_US
dc.identifier.citationMundra, P.A., and J.C. Rajapakse. “SVM-RFE With MRMR Filter for Gene Selection.” NanoBioscience, IEEE Transactions On 9.1 (2010) : 31-37. ©2010 IEEE.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.approverRajapakse, Jagath
dc.contributor.mitauthorRajapakse, Jagath
dc.relation.journalIEEE Transactions on NanoBioscienceen_US
dc.eprint.versionFinal published versionen_US
dc.identifier.pmid19884101
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMundra, P.A.; Rajapakse, J.C.en
mit.licensePUBLISHER_POLICYen_US


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