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dc.contributor.authorKnoblich, Ulf
dc.contributor.authorSiegle, Joshua Handman
dc.contributor.authorPritchett, Dominique Leon
dc.contributor.authorMoore, Christopher I.
dc.date.accessioned2011-05-06T16:38:39Z
dc.date.available2011-05-06T16:38:39Z
dc.date.issued2010-10
dc.date.submitted2010-06
dc.identifier.issn1662-5161
dc.identifier.urihttp://hdl.handle.net/1721.1/62591
dc.description.abstractGamma oscillations in neocortex are hypothesized to improve information transmission between groups of neurons. We recently showed that optogenetic drive of fast-spiking interneurons (FS) at 40 Hz in mouse neocortex in vivo modulates the spike count and precision of sensory evoked responses. At specific phases of alignment between stimuli and FS activation, total evoked spike count was unchanged compared to baseline, but precision was increased. In the present study, we used computational modeling to investigate the origin of these local transformations, and to make predictions about their impact on downstream signal transmission. We replicated the prior experimental findings, and found that the local gain observed can be explained by mutual inhibition of fast-spiking interneurons, leading to more robust sensory-driven spiking in a brief temporal window post-stimulus, increasing local synchrony. Enhanced spiking in a second neocortical area, without a net increase in overall driven spikes in the first area, resulted from faster depolarization of target neurons due to increased pre-synaptic synchrony. In addition, we found that the precise temporal structure of spiking in the first area impacted the gain between cortical areas. The optimal spike distribution matched the “window of opportunity” defined by the timing of inhibition in the target area: spiking beyond this window did not contribute to downstream spike generation, leading to decreased overall gain. This result predicts that efficient transmission between neocortical areas requires a mechanism to dynamically match the temporal structure of the output of one area to the timing of inhibition in the recipient zone.en_US
dc.description.sponsorshipMcGovern Institute of Brain Research at MITen_US
dc.description.sponsorshipNational Defense Science and Engineering Graduate Fellowshipen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Fellowship)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant 5-R01-NS045130-06)en_US
dc.language.isoen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isversionofhttp://dx.doi.org/10.3389/fnhum.2010.00185en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceFrontiersen_US
dc.titleWhat do we gain from gamma? Local dynamic gain modulation drives enhanced efficacy and efficiency of signal transmissionen_US
dc.typeArticleen_US
dc.identifier.citationKnoblich Ulf, Joshua H. Siegle, Dominique L. Pritchett and Christopher I. Moore. "What do we gain from gamma? Local dynamic gain modulation drives enhanced efficacy and efficiency of signal transmission." (2010) Front. Hum. Neurosci. 4:185.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.approverMoore, Christopher I.
dc.contributor.mitauthorMoore, Christopher I.
dc.contributor.mitauthorKnoblich, Ulf
dc.contributor.mitauthorSiegle, Joshua Handman
dc.contributor.mitauthorPritchett, Dominique Leon
dc.relation.journalFrontiers in Human Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKnoblich, Ulf; Siegle, Joshua H.; Pritchett, Dominique L.; Moore, Christopher I.en
dc.identifier.orcidhttps://orcid.org/0000-0002-0756-5587
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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