dc.contributor.author | Choma, Michael A. | |
dc.contributor.author | Suter, Melissa J. | |
dc.contributor.author | Vakoc, Benjamin | |
dc.contributor.author | Bouma, Brett E. | |
dc.contributor.author | Tearney, Guillermo J. | |
dc.date.accessioned | 2011-06-29T20:05:45Z | |
dc.date.available | 2011-06-29T20:05:45Z | |
dc.date.issued | 2010-09 | |
dc.date.submitted | 2010-08 | |
dc.identifier.issn | 1083-3668 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/64711 | |
dc.description.abstract | Drosophila melanogaster (fruit fly) is a central organism in biology and is becoming increasingly important in the cardiovascular sciences. Prior work in optical imaging of the D. melanogaster heart has focused on static and dynamic structural anatomy. In the study, it is demonstrated that Doppler optical coherence tomography can quantify dynamic heart wall velocity and hemolymph flow in adult D. melanogaster. Since hemolymph is optically transparent, a novel exogenous contrast technique is demonstrated to increase the backscatter-based intracardiac Doppler flow signal. The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster. | en_US |
dc.description.sponsorship | Frederick H. Lovejoy Fund | en_US |
dc.description.sponsorship | Children's Hospital (Boston, Mass.) | en_US |
dc.description.sponsorship | AMA Foundation | en_US |
dc.description.sponsorship | AMA Foundation (Seed Grant) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (NIH R01HL076398) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (NIH R01HL076398) | en_US |
dc.description.sponsorship | United States. Air Force Office of Scientific Research (Medical Free Electron Laser Program FA9550-04-1-0079) | en_US |
dc.language.iso | en_US | |
dc.publisher | Society of Photo-optical Instrumentation Engineers | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1117/1.3503418 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | SPIE | en_US |
dc.title | Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Choma, Michael A. et al. “Heart Wall Velocimetry and Exogenous Contrast-based Cardiac Flow Imaging in Drosophila Melanogaster Using Doppler Optical Coherence Tomography.” Journal of Biomedical Optics 15.5 (2010) : 056020-6. © 2010 SPIE. | en_US |
dc.contributor.department | Harvard University--MIT Division of Health Sciences and Technology | en_US |
dc.contributor.approver | Tearney, Guillermo J. | |
dc.contributor.mitauthor | Tearney, Guillermo J. | |
dc.contributor.mitauthor | Vakoc, Benjamin | |
dc.contributor.mitauthor | Bouma, Brett E. | |
dc.relation.journal | Journal of Biomedical Optics | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Choma, Michael A.; Suter, Melissa J.; Vakoc, Benjamin J.; Bouma, Brett E.; Tearney, Guillermo J. | en |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |