dc.contributor.author | Wilson, Justin Jeff | |
dc.contributor.author | Fedoce Lopes, Juliana | |
dc.contributor.author | Lippard, Stephen J. | |
dc.date.accessioned | 2011-07-07T19:02:54Z | |
dc.date.available | 2011-07-07T19:02:54Z | |
dc.date.issued | 2010-03 | |
dc.identifier.issn | 0020-1669 | |
dc.identifier.issn | 1520-510X | |
dc.identifier.uri | http://hdl.handle.net/1721.1/64766 | |
dc.description.abstract | Three new ligands of the general formula [RNHCH(py)2] (py = pyridine; R = tosyl, Ts-dpm; R = dansyl, Ds-dpm; R = 7-nitro-1,2,3-benzoxadiazole, NBD-dpm) have been synthesized and characterized. Reactions of these ligands with cis-[Pt(DMSO)2Cl2] (DMSO = dimethyl sulfoxide) in methanol affords [Pt(Ts-dpm)Cl2] (1), [Pt(Ds-dpm)Cl2] (2), and [Pt(NBD-dpm)Cl2] (3). The crystal structures of these complexes reveal bidentate coordination of the ligands to the Pt center with nonplanar chelate rings. Because of inequivalent substituents on the methine carbon atom of the ligands, distinct exo and endo isomers exist in the three complexes. X-ray analyses indicate that 1 crystallizes in the endo conformation, 2 in the exo conformation, and 3 as a mixture of the two conformers. The 1H NMR and 195Pt NMR spectra of the complexes display two sets of independent signals corresponding to the chemically inequivalent exo and endo conformers. The exo conformer was determined by 2D NMR spectroscopy to be thermodynamically favored for all three complexes. Density functional theory (DFT), time-dependent DFT, and atoms in molecules calculations were carried out for both conformers of 3 to investigate differences in their electronic structures and to explore intramolecular interactions. In the presence of dioxygen, 1 thermally decomposes at 60 °C to form several unidentified products. Compound 2 is thermally stable even in the presence of dioxygen and water but upon light exposure decomposes to form a new platinum(II) species with a 195Pt NMR shift of −2177 ppm. Compound 3 reacts both thermally and photochemically in the presence of dioxygen and trace amounts of water to form both 4-amino-7-nitro-2,1,3-benzoxadiazole and [Pt(dpk)Cl2] (dpk = di-2-pyridyl ketone). Oxidation of 1 and 3 with H2O2 in acetic acid affords a mixture of compounds, two of which contain dpm ligands bound in a tridentate manner to platinum. | en_US |
dc.description.sponsorship | National Cancer Institute (U.S.) (CA034992) | en_US |
dc.description.sponsorship | Brazil. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Post-doctoral Fellowship (process 4470-08-7)) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/ic100411p | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Prof. Lippard via Erja Kajosalo | en_US |
dc.title | Synthesis, Characterization, and Photophysical Properties of Three Pt(II) Complexes Bearing Fluorescent Analogues of the Di-(2-pyridyl)methane Ligand | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Wilson, Justin J., Juliana Fedoce Lopes, and Stephen J. Lippard. “Synthesis, Characterization, and Photophysical Properties of Three Platinum(II) Complexes Bearing Fluorescent Analogues of the Di-2-pyridylmethane Ligand.” Inorganic Chemistry 49.11 (2010) : 5303-5315. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.approver | Lippard, Stephen J. | |
dc.contributor.mitauthor | Wilson, Justin Jeff | |
dc.contributor.mitauthor | Fedoce Lopes, Juliana | |
dc.contributor.mitauthor | Lippard, Stephen J. | |
dc.relation.journal | Inorganic Chemistry | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Wilson, Justin J.; Fedoce Lopes, Juliana; Lippard, Stephen J. | en |
dc.identifier.orcid | https://orcid.org/0000-0002-2693-4982 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |