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dc.contributor.authorYang, Yue
dc.contributor.authorHuang, Jinghe
dc.contributor.authorToth, Ildiko
dc.contributor.authorLichterfeld, Mathias
dc.contributor.authorYu, Xu G.
dc.date.accessioned2011-07-20T21:05:06Z
dc.date.available2011-07-20T21:05:06Z
dc.date.issued2010-12
dc.date.submitted2010-08
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/64947
dc.description.abstractEscape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that mutational escape in three HLA-A11-, B8- and B7- restricted immunodominant HIV-1 CTL epitopes consistently enhances binding of the respective peptide/MHC class I complex to Immunoglobulin-like transcript 4 (ILT4), an inhibitory myelomonocytic MHC class I receptor expressed on monocytes and dendritic cells. In contrast, mutational escape in an alternative immunodominant HLA-B57-restricted CTL epitope did not affect ILT4-mediated recognition by myelomonocytic cells. This suggests that in addition to abrogating recognition by HIV-1-specific CD8 T cells, mutational escape in some, but not all CTL epitopes may mediate important immunoregulatory effects by increasing binding properties to ILT4, and augmenting ILT4-mediated inhibitory effects of professional antigen-presenting cells.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01 AI078799)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant P01 AI074415)en_US
dc.description.sponsorshipDoris Duke Charitable Foundationen_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0015084en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en_US
dc.sourcePLoSen_US
dc.titleMutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptorsen_US
dc.typeArticleen_US
dc.identifier.citationYang, Yue, Huang J, Toth I, Lichterfeld M, Yu XG (2010) Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors. PLoS ONE 5(12): e15084. © 2010 Yang et al.en_US
dc.contributor.approverYang, Yue
dc.contributor.mitauthorYang, Yue
dc.relation.journalPLoS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsYang, Yue; Huang, Jinghe; Toth, Ildiko; Lichterfeld, Mathias; Yu, Xu G.en
mit.licensePUBLISHER_CCen_US


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