dc.contributor.author | Hsu, Bryan Boen | |
dc.contributor.author | Wong, Sze Yinn | |
dc.contributor.author | Chen, Jianzhu | |
dc.contributor.author | Klibanov, Alexander M. | |
dc.contributor.author | Hammond, Paula T | |
dc.date.accessioned | 2011-07-28T15:24:50Z | |
dc.date.available | 2011-07-28T15:24:50Z | |
dc.date.issued | 2011-01 | |
dc.date.submitted | 2010-10 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/64967 | |
dc.description.abstract | N,N-Dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed. | en_US |
dc.description.sponsorship | MIT/Army Institute for Soldier Nanotechnologies (contract DAAD-19-02-D0002) | en_US |
dc.description.sponsorship | United States. Army Research Office | en_US |
dc.language.iso | en_US | |
dc.publisher | National Academy of Sciences (U.S.) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1073/pnas.1017012108 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PNAS | en_US |
dc.title | Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Hsu, B. B. et al. “Mechanism of Inactivation of Influenza Viruses by Immobilized Hydrophobic Polycations.” Proceedings of the National Academy of Sciences 108.1 (2011) : 61-66. ©2011 by the National Academy of Sciences. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.approver | Klibanov, Alexander M. | |
dc.contributor.mitauthor | Klibanov, Alexander M. | |
dc.contributor.mitauthor | Wong, Sze Yinn | |
dc.contributor.mitauthor | Hammond, Paula T. | |
dc.contributor.mitauthor | Chen, Jianzhu | |
dc.contributor.mitauthor | Hsu, Bryan Boen | |
dc.relation.journal | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Hsu, B. B.; Yinn Wong, S.; Hammond, P. T.; Chen, J.; Klibanov, A. M. | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-3830-714X | |
dc.identifier.orcid | https://orcid.org/0000-0002-5687-6154 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |