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dc.contributor.authorHsu, Bryan Boen
dc.contributor.authorWong, Sze Yinn
dc.contributor.authorChen, Jianzhu
dc.contributor.authorKlibanov, Alexander M.
dc.contributor.authorHammond, Paula T
dc.date.accessioned2011-07-28T15:24:50Z
dc.date.available2011-07-28T15:24:50Z
dc.date.issued2011-01
dc.date.submitted2010-10
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1721.1/64967
dc.description.abstractN,N-Dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.en_US
dc.description.sponsorshipMIT/Army Institute for Soldier Nanotechnologies (contract DAAD-19-02-D0002)en_US
dc.description.sponsorshipUnited States. Army Research Officeen_US
dc.language.isoen_US
dc.publisherNational Academy of Sciences (U.S.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.1017012108en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePNASen_US
dc.titleMechanism of inactivation of influenza viruses by immobilized hydrophobic polycationsen_US
dc.typeArticleen_US
dc.identifier.citationHsu, B. B. et al. “Mechanism of Inactivation of Influenza Viruses by Immobilized Hydrophobic Polycations.” Proceedings of the National Academy of Sciences 108.1 (2011) : 61-66. ©2011 by the National Academy of Sciences.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.approverKlibanov, Alexander M.
dc.contributor.mitauthorKlibanov, Alexander M.
dc.contributor.mitauthorWong, Sze Yinn
dc.contributor.mitauthorHammond, Paula T.
dc.contributor.mitauthorChen, Jianzhu
dc.contributor.mitauthorHsu, Bryan Boen
dc.relation.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHsu, B. B.; Yinn Wong, S.; Hammond, P. T.; Chen, J.; Klibanov, A. M.en_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3830-714X
dc.identifier.orcidhttps://orcid.org/0000-0002-5687-6154
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


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