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Active scaffolds for on-demand drug and cell delivery

Author(s)
Zhao, Xuanhe; Kim, Jaeyun; Cezar, Christine A.; Huebsch, Nathaniel David; Lee, Kangwon; Bouhadir, Kamal; Mooney, David J.; ... Show more Show less
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Abstract
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.
Date issued
2011-01
URI
http://hdl.handle.net/1721.1/64971
Department
Harvard University--MIT Division of Health Sciences and Technology
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Zhao, X. et al. “Active Scaffolds for On-demand Drug and Cell Delivery.” Proceedings of the National Academy of Sciences 108.1 (2011) : 67-72.©2011 by the National Academy of Sciences.
Version: Final published version
ISSN
0027-8424
1091-6490

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