The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation
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Lrs4 and Csm1, components of the monopolin complex, localize to the rDNA where they regulate rDNA maintenance
and segregation. During meiosis, the complex also associates with kinetochores to bring about sister kinetochore
co-orientation, an essential aspect of meiosis I chromosome segregation. We show here that the Lrs4-Csm1 complex
associates with kinetochores during mitosis. This kinetochore localization is observed during anaphase and depends on
the on the Mitotic Exit Network, a signaling cascade essential for the completion of mitosis. Furthermore, we find that
Lrs4 and Csm1 are important for chromosome segregation fidelity. Our results reveal a previously unanticipated function
for Lrs4-Csm1 in mitotic chromosome segregation.
Date issued
2010-09Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Civil and Environmental Engineering; Koch Institute for Integrative Cancer Research at MITJournal
Cell Cycle
Publisher
Landes Bioscience
Citation
Brito, Ilana, Fernando Monje-Casas, and Angelika Amon. “The Lrs4-Csm1 Monopolin Complex Associates with Kinetochores During Anaphase and Is Required for Accurate Chromosome Segregation.” Cell Cycle 9.17 (2010) : 3611-3618. Web. 15 Sept 2011.
Version: Final published version
ISSN
1551-4005
1538-4101