Divergent Pathways in the Biosynthesis of Bisindole Natural Products
Author(s)
Ryan, Katherine S.; Drennan, Catherine L
DownloadMain article (295.1Kb)
OPEN_ACCESS_POLICY
Open Access Policy
Creative Commons Attribution-Noncommercial-Share Alike
Terms of use
Metadata
Show full item recordAbstract
Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the “bisindoles.” Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties. Recent studies have clarified the biosynthetic construction of six bisindole molecules, revealing novel enzymatic mechanisms and leading to combinatorial synthesis of new bisindole compounds. Collectively, these results provide a vantage point for understanding how much of the diversity of the bisindole class is generated from a small number of diverging pathways from L-tryptophan, as well as enabling identification of bisindoles that are likely derived via completely distinct biosynthetic pathways.
Date issued
2009-04Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of ChemistryJournal
Chemistry and Biology
Publisher
Elsevier
Citation
Ryan, Katherine S., and Catherine L. Drennan. “Divergent Pathways in the Biosynthesis of Bisindole Natural Products.” Chemistry & Biology 16.4 (2009) : 351-364.
Version: Author's final manuscript