A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
Author(s)Bernstein, Bradley E.; Epstein, Charles B.; Shoresh, Noam; Ernst, Jason; Mikkelsen, Tarjei Sigurd; Kheradpour, Pouya; Zhang, Xiaolan; Wang, Li; Issner, Robbyn; Coyne, Michael J.; Durham, Timothy; Ku, Manching; Truong, Thanh; Ward, Lucas D.; Altshuler, Robert Charles; Lin, Michael F.; Kellis, Manolis; ENCODE Project Consortium; ... Show more Show less
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The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.
DepartmentBroad Institute of MIT and Harvard; Lincoln Laboratory; Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Physics
Public Library of Science
The ENCODE Project Consortium (2011) "A User’s Guide to the Encyclopedia of DNA Elements (ENCODE)." PLoS Biology 9(4): e1001046.
Final published version