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dc.contributor.authorDragoi, George
dc.contributor.authorTonegawa, Susumu
dc.date.accessioned2011-10-24T15:17:10Z
dc.date.available2011-10-24T15:17:10Z
dc.date.issued2011-01
dc.identifier.issn0028-0836
dc.identifier.issn1476-4687
dc.identifier.urihttp://hdl.handle.net/1721.1/66548
dc.description.abstractDuring spatial exploration, hippocampal neurons show a sequential firing pattern in which individual neurons fire specifically at particular locations along the animal’s trajectory (place cells1, 2). According to the dominant model of hippocampal cell assembly activity, place cell firing order is established for the first time during exploration, to encode the spatial experience, and is subsequently replayed during rest3, 4, 5, 6 or slow-wave sleep7, 8, 9, 10 for consolidation of the encoded experience11, 12. Here we report that temporal sequences of firing of place cells expressed during a novel spatial experience occurred on a significant number of occasions during the resting or sleeping period preceding the experience. This phenomenon, which is called preplay, occurred in disjunction with sequences of replay of a familiar experience. These results suggest that internal neuronal dynamics during resting or sleep organize hippocampal cellular assemblies13, 14, 15 into temporal sequences that contribute to the encoding of a related novel experience occurring in the future.en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/nature09633en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceTonegawaen_US
dc.titlePreplay of future place cell sequences by hippocampal cellular assembliesen_US
dc.typeArticleen_US
dc.identifier.citationDragoi, George, and Susumu Tonegawa. “Preplay of future place cell sequences by hippocampal cellular assemblies.” Nature 469 (2010): 397-401.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.approverTonegawa, Susumu
dc.contributor.mitauthorTonegawa, Susumu
dc.contributor.mitauthorDragoi, George
dc.relation.journalNatureen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsDragoi, George; Tonegawa, Susumuen
dc.identifier.orcidhttps://orcid.org/0000-0003-2839-8228
mit.licenseOPEN_ACCESS_POLICYen_US


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