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dc.contributor.authorBellott, Daniel W.
dc.contributor.authorPage, David C.
dc.date.accessioned2011-10-25T15:48:06Z
dc.date.available2011-10-25T15:48:06Z
dc.date.issued2010-01
dc.identifier.issn0091-7451
dc.identifier.urihttp://hdl.handle.net/1721.1/66577
dc.descriptionhttp://symposium.cshlp.org/content/74/345.full.pdf+htmlen_US
dc.description.abstractSex chromosomes and their evolution have captivated researchers since their discovery. For more than 100 years, the dominant model of sex chromosome evolution has held that differentiated sex chromosomes, such as the X and Y chromosomes of mammals or the Z and W chromosomes of birds, evolved from ordinary autosomes, primarily through the degeneration of the sex-specific Y or W chromosome. At the same time, the sex chromosomes shared between sexes, the X and Z chromosomes, are expected to remain essentially untouched. This model was based on limited cytogenetic and genetic data. Only in the last decade, with the advent of genomics, has the complete sequence of any sex chromosome pair become available. High-quality finished sequences of the human and chimpanzee Y chromosomes, as well as the human X chromosome, have revealed sequence features unanticipated by the traditional model of sex chromosome evolution. Large, highly identical, tandem and inverted arrays of testis-expressed genes are major sources of innovation in gene content on sex-specific chromosomes as well as sex-shared chromosomes. Accounting for the emergence of these ampliconic structures presents a challenge for future studies of sex chromosome evolution.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.)en_US
dc.description.sponsorshipHoward Hughes Medical Instituteen_US
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratoryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1101/sqb.2009.74.048en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePageen_US
dc.titleReconstructing the Evolution of Vertebrate Sex Chromosomesen_US
dc.typeArticleen_US
dc.identifier.citationBellott, D.W. and D.C. Page."Reconstructing the Evolution of Vertebrate Sex Chromosomes." Cold Spring Harbor Symposia on Quantitative Biology, 2009. 74: 345-353.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.approverPage, David C.
dc.contributor.mitauthorPage, David C.
dc.contributor.mitauthorBellott, Daniel W.
dc.relation.journalCold Spring Harbor Symposia on Quantitative Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/ConferencePaperen_US
dspace.orderedauthorsBellott, D. W.; Page, D. C.en
dc.identifier.orcidhttps://orcid.org/0000-0001-9920-3411
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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