Finite Element Framework for Mechanics and Dynamics of Supramolecular Protein Assemblies
Author(s)Kim, Do-Nyun; Sharifi Sedeh, Reza; Nguyen, Cong Tri; Bathe, Mark
MetadataShow full item record
Introducation: The conformational dynamics and mechanical properties of supramolecular protein assemblies play a central role in a broad array of cellular functions ranging from migration and division to transcription and translation. The finite element method (FEM) provides a natural framework for the computation of protein normal modes and mechanical response based either on atomic coordinates or electron density maps . Here, we present development of the finite element framework for the computation of actin filament mechanics and solvent damping effects. A new normal modes data bank for structures in the electron microscopy data bank (EMDB ) is also presented.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering; Massachusetts Institute of Technology. Laboratory for Computational Cell Biology & Biophysics
Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010)
American Society of Mechanical Engineers
Kim, Do-Nyun et al. "Finite Element Framework for Mechanics and Dynamics of Supramolecular Protein Assemblies." in Proceedings of ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology NEMB2010, February 7-10, 2010 Houston, TX, USA. © 2010 ASME.
Final published version