dc.contributor.author | Florian, Cedrick | |
dc.contributor.author | Vecsey, Christopher G. | |
dc.contributor.author | Haydon, Philip G. | |
dc.contributor.author | Abel, Ted | |
dc.contributor.author | Halassa, Michael M. | |
dc.date.accessioned | 2012-02-08T21:23:02Z | |
dc.date.available | 2012-02-08T21:23:02Z | |
dc.date.issued | 2011-05 | |
dc.date.submitted | 2011-02 | |
dc.identifier.issn | 0270-6474 | |
dc.identifier.issn | 1529-2401 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/69057 | |
dc.description.abstract | Sleep deprivation (SD) can have a negative impact on cognitive function, but the mechanism(s) by which SD modulates memory remains unclear. We have previously shown that astrocyte-derived adenosine is a candidate molecule involved in the cognitive deficits following a brief period of SD (Halassa et al., 2009). In this study, we examined whether genetic disruption of soluble N-ethylmaleimide-sensitive factor attached protein (SNARE)-dependent exocytosis in astrocytes (dnSNARE mice) or pharmacological blockade of A1 receptor signaling using an adenosine A1 receptor (A1R) antagonist, 8-cyclopentyl-1,3-dimethylxanthine (CPT), could prevent the negative effects of 6 h of SD on hippocampal late-phase long-term potentiation (L-LTP) and hippocampus-dependent spatial object recognition memory. We found that SD impaired L-LTP in wild-type mice but not in dnSNARE mice. Similarly, this deficit in L-LTP resulting from SD was prevented by a chronic infusion of CPT. Consistent with these results, we found that hippocampus-dependent memory deficits produced by SD were rescued in dnSNARE mice and CPT-treated mice. These data provide the first evidence that astrocytic ATP and adenosine A1R activity contribute to the effects of SD on hippocampal synaptic plasticity and hippocampus-dependent memory, and suggest a new therapeutic target to reverse the hippocampus-related cognitive deficits induced by sleep loss. | en_US |
dc.description.sponsorship | United States. National Institutes of Health (P50 Grant AG017628) | en_US |
dc.description.sponsorship | United States. National Institutes of Health (Training Grant HL07953) | en_US |
dc.description.sponsorship | United States. National Institutes of Health (Grant R01 NS037585) | en_US |
dc.description.sponsorship | United States. National Institutes of Health (Grant R01 NS043142) | en_US |
dc.language.iso | en_US | |
dc.publisher | Society for Neuroscience | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1523/jneurosci.5761-10.2011 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | SFN | en_US |
dc.title | Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Florian, C. et al. “Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice.” Journal of Neuroscience 31.19 (2011): 6956-6962. Web. 8 Feb. 2012. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.approver | Halassa, Michael M. | |
dc.contributor.mitauthor | Halassa, Michael M. | |
dc.relation.journal | Journal of Neuroscience | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Florian, C.; Vecsey, C. G.; Halassa, M. M.; Haydon, P. G.; Abel, T. | en |
dspace.mitauthor.error | true | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |