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Towards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators

dc.contributor.authorLee, Jungchul
dc.contributor.authorShen, Wenjiang
dc.contributor.authorPayer, Kristofor Robert
dc.contributor.authorBurg, Thomas P.
dc.contributor.authorManalis, Scott R.
dc.date.accessioned2012-02-10T16:39:39Z
dc.date.available2012-02-10T16:39:39Z
dc.date.issued2011-07
dc.date.submitted2010-03
dc.identifier.issn1530-6984
dc.identifier.issn1530-6992
dc.identifier.urihttp://hdl.handle.net/1721.1/69077
dc.description.abstractUsing suspended nanochannel resonators (SNRs) we demonstrate measurements of mass in solution with a resolution of 27 ag in a 1 kHz bandwidth, which represents a 100-fold improvement over existing suspended microchannel resonators and, to our knowledge, is the most precise mass measurement in liquid today. The SNR consists of a cantilever that is 50 μm long, 10 μm wide, and 1.3 μm thick, with an embedded nanochannel that is 2 μm wide and 700 nm tall. The SNR has a resonance frequency near 630 kHz and exhibits a quality factor of approximately 8,000 when dry and when filled with water. In addition, we introduce a new method that uses centrifugal force caused by vibration of the cantilever to trap particles at the free end. This approach eliminates the intrinsic position dependent error of the SNR and also improves the mass resolution by increasing the averaging time for each particle.en_US
dc.description.sponsorshipCenter for Integration of Medicine and Innovative Technology (CIMIT Contract 09-440)en_US
dc.description.sponsorshipUnited States. Army Research Office (Institute for Collaborative Biotechnologies Grant (DAAD1903D0004))en_US
dc.description.sponsorshipMax Planck Institute for Biophysical Chemistryen_US
dc.language.isoen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/nl101107uen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceProf. Manalis via Howard Silveren_US
dc.titleTowards Attogram Mass Measurements in Solution with Suspended Nanochannel Resonatorsen_US
dc.title.alternativeToward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonatorsen_US
dc.typeArticleen_US
dc.identifier.citationLee, Jungchul et al. “Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators.” Nano Letters 10.7 (2010): 2537-2542.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Mechanical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Microsystems Technology Laboratoriesen_US
dc.contributor.approverManalis, Scott R.
dc.contributor.mitauthorManalis, Scott R.
dc.contributor.mitauthorLee, Jungchul
dc.contributor.mitauthorPayer, Kristofor Robert
dc.relation.journalNano Lettersen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLee, Jungchul; Shen, Wenjiang; Payer, Kris; Burg, Thomas P.; Manalis, Scott R.en
dc.identifier.orcidhttps://orcid.org/0000-0001-5223-9433
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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