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dc.contributor.authorMandelblat-Cerf, Yael
dc.contributor.authorNovick, Itai
dc.contributor.authorVaadia, Eilon
dc.date.accessioned2012-02-10T19:54:04Z
dc.date.available2012-02-10T19:54:04Z
dc.date.issued2011-07
dc.date.submitted2011-04
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/69090
dc.description.abstractPrevious studies support the notion that sensorimotor learning involves multiple processes. We investigated the neuronal basis of these processes by recording single-unit activity in motor cortex of non-human primates (Macaca fascicularis), during adaptation to force-field perturbations. Perturbed trials (reaching to one direction) were practiced along with unperturbed trials (to other directions). The number of perturbed trials relative to the unperturbed ones was either low or high, in two separate practice schedules. Unsurprisingly, practice under high-rate resulted in faster learning with more pronounced generalization, as compared to the low-rate practice. However, generalization and retention of behavioral and neuronal effects following practice in high-rate were less stable; namely, the faster learning was forgotten faster. We examined two subgroups of cells and showed that, during learning, the changes in firing-rate in one subgroup depended on the number of practiced trials, but not on time. In contrast, changes in the second subgroup depended on time and practice; the changes in firing-rate, following the same number of perturbed trials, were larger under high-rate than low-rate learning. After learning, the neuronal changes gradually decayed. In the first subgroup, the decay pace did not depend on the practice rate, whereas in the second subgroup, the decay pace was greater following high-rate practice. This group shows neuronal representation that mirrors the behavioral performance, evolving faster but also decaying faster at learning under high-rate, as compared to low-rate. The results suggest that the stability of a new learned skill and its neuronal representation are affected by the acquisition schedule.en_US
dc.description.sponsorshipUnited States-Israel Binational Science Foundationen_US
dc.description.sponsorshipIsrael Science Foundationen_US
dc.description.sponsorshipIda Baruch Funden_US
dc.description.sponsorshipRosetrees Trusten_US
dc.language.isoen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0021626en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en_US
dc.sourcePLoSen_US
dc.titleExpressions of Multiple Neuronal Dynamics during Sensorimotor Learning in the Motor Cortex of Behaving Monkeysen_US
dc.typeArticleen_US
dc.identifier.citationMandelblat-Cerf, Yael, Itai Novick, and Eilon Vaadia. “Expressions of Multiple Neuronal Dynamics During Sensorimotor Learning in the Motor Cortex of Behaving Monkeys.” Ed. Georges Chapouthier. PLoS ONE 6.7 (2011): e21626. Web. 10 Feb. 2012.en_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.approverMandelblat-Cerf, Yael
dc.contributor.mitauthorMandelblat-Cerf, Yael
dc.relation.journalPLoS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMandelblat-Cerf, Yael; Novick, Itai; Vaadia, Eilonen
mit.licensePUBLISHER_CCen_US
mit.metadata.statusComplete


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