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Towards accurate imputation of quantitative genetic interactions

Author(s)
Krogan, Nevan J.; Shamir, Ron; Ulitsky, Igor
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Abstract
Recent technological breakthroughs have enabled high-throughput quantitative measurements of hundreds of thousands of genetic interactions among hundreds of genes in Saccharomyces cerevisiae. However, these assays often fail to measure the genetic interactions among up to 40% of the studied gene pairs. Here we present a novel method, which combines genetic interaction data together with diverse genomic data, to quantitatively impute these missing interactions. We also present data on almost 190,000 novel interactions.
Date issued
2009-12
URI
http://hdl.handle.net/1721.1/69538
Department
Whitehead Institute for Biomedical Research
Journal
Genome Biology
Publisher
Springer (Biomed Central Ltd.)
Citation
Ulitsky, Igor, Nevan J Krogan, and Ron Shamir. “Towards Accurate Imputation of Quantitative Genetic Interactions.” Genome Biology 10.12 (2009): R140. Web. 1 Mar. 2012.
Version: Final published version
ISSN
1465-6906
1474-7596

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