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Relative contribution of feed-forward excitatory connections to expression of ocular dominance plasticity in layer 4 of visual cortex

Author(s)
Khibnik, Lena A.; Cho, Kathleen K.; Bear, Mark
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Abstract
Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only “feedforward” thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission.
Date issued
2010-05
URI
http://hdl.handle.net/1721.1/69541
Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Journal
Neuron
Publisher
Elsevier B.V.
Citation
Khibnik, Lena A., Kathleen K.A. Cho, and Mark F. Bear. “Relative Contribution of Feedforward Excitatory Connections to Expression of Ocular Dominance Plasticity in Layer 4 of Visual Cortex.” Neuron 66.4 (2010): 493–500.
Version: Author's final manuscript

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