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dc.contributor.authorAlonso, Alvaro
dc.contributor.authorJick, Susan S.
dc.contributor.authorLogroscino, Giancarlo
dc.contributor.authorHernan, Miguel Angel
dc.date.accessioned2012-03-01T18:29:59Z
dc.date.available2012-03-01T18:29:59Z
dc.date.issued2010-01
dc.date.submitted2009-08
dc.identifier.issn1471-2377
dc.identifier.issn1471-2377
dc.identifier.urihttp://hdl.handle.net/1721.1/69546
dc.description.abstractBackground Previous epidemiologic studies have examined the association of smoking with amyotrophic lateral sclerosis (ALS) incidence, but their results have been inconsistent. Moreover, limited information exists on the association between smoking and survival in ALS patients. We evaluated the association of smoking with ALS incidence and survival in a population-based cohort. Methods We conducted a case-control study nested in the General Practice Research Database, a computerized clinical database in the United Kingdom. Cases were 1143 individuals with a diagnosis of ALS; 11,371 matched controls were selected among GPRD participants free of ALS. Predictors of survival were determined in the ALS cases. Smoking information was obtained from the computer database. Results Smoking was not associated with the risk of ALS in this population. The rate ratio (RR) of ALS comparing ever versus never smokers was 1.04, 95% confidence interval (CI) 0.80-1.34. In analysis stratified by gender, however, ever smoking was associated with ALS in women (RR 1.53, 95% CI 1.04-2.23) but not in men (RR 0.75, 95% CI 0.53-1.06). Mortality was 71% after 2.1 average years of follow-up. Old age and female sex were associated with lower survival. Smoking was a predictor of mortality only in women. Comparing ever versus never smokers, RR (95% CI) of death was 1.31 (1.04-1.65) in women, and 0.90 (0.72-1.11) in men. Conclusion In this large population-based study, smoking was associated with ALS risk and worse survival in women but not in men.en_US
dc.description.sponsorshipUniversity of Minnesota. Graduate School (Grant-in-Aid)en_US
dc.description.sponsorshipHarvard University. Program on the Global Epidemiology of Aging (grant NIH/NIA P30 AG024409-03 f)en_US
dc.language.isoen_US
dc.publisherSpringer (Biomed Central Ltd.)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1186/1471-2377-10-6en_US
dc.rightsCreative Commons Attributionen_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_US
dc.sourceBioMed Centralen_US
dc.titleAssociation of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective studyen_US
dc.typeArticleen_US
dc.identifier.citationAlonso, Alvaro et al. “Association of Smoking with Amyotrophic Lateral Sclerosis Risk and Survival in Men and Women: a Prospective Study.” BMC Neurology 10.1 (2010): 6. Web. 1 Mar. 2012.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.approverHernan, Miguel Angel
dc.contributor.mitauthorHernan, Miguel Angel
dc.relation.journalBMC Neurologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsAlonso, Alvaro; Logroscino, Giancarlo; Jick, Susan S; Hernán, Miguel Aen
mit.licensePUBLISHER_CCen_US


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