Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions
Author(s)Chung, Seok; Sudo, Ryo; Vickerman, Vernella Velonie V.; Zervantonakis, Ioannis; Kamm, Roger Dale
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Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide enormous flexibility in controlling the critical biochemical and biomechanical factors that influence cell behavior, (ii) allow for the introduction of multiple cell types in a single system, (iii) provide for the establishment of biochemical gradients in two- or three-dimensional geometries, and (iv) allow for high quality, time-lapse imaging. Here, some of the recent developments are reviewed, with a focus on studies from our own laboratory in three separate areas: angiogenesis, cell migration in the context of tumor cell-endothelial interactions, and liver tissue engineering.
Position paper: Sixth International Bio-Fluid Mechanics Symposium and Workshop March 28–30, 2008 Pasadena, California
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of Mechanical Engineering
Annals of Biomedical Engineering
Springer-Verlag/Biomedical Engineering Society
Chung, Seok et al. “Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions” Annals of Biomedical Engineering 38.3 (2010): 1164–1177.
Author's final manuscript