Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast?
Author(s)Khurana, Vikram; Lindquist, Susan
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In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple complementary experimental approaches are needed to elucidate the mechanisms underlying these complex diseases and to develop novel therapeutics. Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale.
DepartmentMassachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Nature Reviews Neuroscience
Nature Publishing Group
Khurana, Vikram, and Susan Lindquist. “Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker’s yeast?” Nature Reviews Neuroscience 11.6 (2010): 436-449.
Author's final manuscript