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dc.contributor.authorPurdon, Patrick Lee
dc.contributor.authorPierce, Eric T.
dc.contributor.authorBonmassar, Giorgio
dc.contributor.authorWalsh, John
dc.contributor.authorHarrell, P. Grace
dc.contributor.authorKwo, Jean
dc.contributor.authorDeschler, Daniel
dc.contributor.authorBarlow, Margaret
dc.contributor.authorMerhar, Rebecca C.
dc.contributor.authorLamus Garcia Herreros, Camilo
dc.contributor.authorMullaly, Catherine M.
dc.contributor.authorMaginnis, Sharon
dc.contributor.authorSkoniecki, Debra
dc.contributor.authorHiggins, Helen-Anne
dc.contributor.authorBrown, Emery N.
dc.date.accessioned2012-04-13T14:46:30Z
dc.date.available2012-04-13T14:46:30Z
dc.date.issued2009-03
dc.identifier.issn0077-8923
dc.identifier.issn1749-6632
dc.identifier.urihttp://hdl.handle.net/1721.1/70011
dc.description.abstractIt has been long appreciated that anesthetic drugs induce stereotyped changes in electroencephalogram (EEG), but the relationships between the EEG and underlying brain function remain poorly understood. Functional imaging methods including positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), have become important tools for studying how anesthetic drugs act in the human brain to induce the state of general anesthesia. To date, no investigation has combined functional MRI with EEG to study general anesthesia. We report here a paradigm for conducting combined fMRI and EEG studies of human subjects under general anesthesia. We discuss the several technical and safety problems that must be solved to undertake this type of multimodal functional imaging and show combined recordings from a human subject. Combined fMRI and EEG exploits simultaneously the high spatial resolution of fMRI and the high temporal resolution of EEG. In addition, combined fMRI and EEG offers a direct way to relate established EEG patterns induced by general anesthesia to changes in neural activity in specific brain regions as measured by changes in fMRI blood oxygen level dependent (BOLD) signals.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant DP1-OD003646)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant K25-NS05758)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant M01-RR-01066)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant RR025758- 01)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant RR025758- 01)en_US
dc.description.sponsorshipMassachusetts General Hospital. Dept. of Anesthesia and Critical Careen_US
dc.language.isoen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1111/j.1749-6632.2008.04119.xen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePubMed Centralen_US
dc.titleSimultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesiaen_US
dc.typeArticleen_US
dc.identifier.citationPurdon, Patrick L. et al. “Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesia.” Annals of the New York Academy of Sciences 1157.1 (2009): 61–70. Web.en_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.approverBrown, Emery N.
dc.contributor.mitauthorLamus Garcia Herreros, Camilo
dc.contributor.mitauthorPurdon, Patrick Lee
dc.contributor.mitauthorBrown, Emery N.
dc.relation.journalAnnals of the New York Academy of Sciencesen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsPurdon, Patrick L.; Pierce, Eric T.; Bonmassar, Giorgio; Walsh, John; Harrell, P. Grace; Kwo, Jean; Deschler, Daniel; Barlow, Margaret; Merhar, Rebecca C.; Lamus, Camilo; Mullaly, Catherine M.; Sullivan, Mary; Maginnis, Sharon; Skoniecki, Debra; Higgins, Helen-Anne; Brown, Emery N.en
dc.identifier.orcidhttps://orcid.org/0000-0001-5651-5060
dc.identifier.orcidhttps://orcid.org/0000-0003-2668-7819
dc.identifier.orcidhttps://orcid.org/0000-0002-6777-7979
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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