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Y-family DNA polymerases in Escherichia coli

Author(s)
Jarosz, Daniel F.; Beuning, Penny J.; Cohen, Susan E.; Walker, Graham C.
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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Abstract
The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive process. Genetic and biochemical studies have revealed that umuC+ and its homolog dinB+ encode novel DNA polymerases with the ability to catalyze synthesis past DNA lesions that otherwise stall replication – a process termed translesion synthesis (TLS). Similar polymerases have been identified in nearly all organisms, constituting a new enzyme superfamily. Although typically viewed as unfaithful copiers of DNA, recent studies suggest that certain TLS polymerases can perform proficient and moderately accurate bypass of particular types of DNA damage. Moreover, various cellular factors can modulate their activity and mutagenic potential.
Date issued
2007-01
URI
http://hdl.handle.net/1721.1/70041
Department
Massachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Chemistry
Journal
Trends in Microbiology
Publisher
Elsevier
Citation
Jarosz, Daniel F. et al. “Y-family DNA Polymerases in Escherichia Coli.” Trends in Microbiology 15.2 (2007): 70–77. Web. 13 Apr. 2012. © 2007 Elsevier Ltd.
Version: Final published version
ISSN
0966-842X
1878-4380

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