Metagenomic biomarker discovery and explanation
Author(s)
Segata, Nicola; Izard, Jacques; Waldron, Levi; Gevers, Dirk; Miropolsky, Larisa; Garrett, Wendy S.; Huttenhower, Curtis; ... Show more Show less
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This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.
Date issued
2011-06Department
Harvard University--MIT Division of Health Sciences and TechnologyJournal
Genome Biology
Publisher
Springer (Biomed Central Ltd.)
Citation
Segata, Nicola et al. “Metagenomic Biomarker Discovery and Explanation.” Genome Biology 12.6 (2011): R60. Web.
Version: Final published version
ISSN
1465-6906
1474-7596