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dc.contributor.authorAiroldi, Edoardo M.
dc.contributor.authorSlavov, Nikolai G.
dc.contributor.authorvan Oudenaarden, Alexander
dc.contributor.authorBotstein, David
dc.date.accessioned2012-05-04T19:02:19Z
dc.date.available2012-05-04T19:02:19Z
dc.date.issued2012-03
dc.date.submitted2012-01
dc.identifier.issn1059-1524
dc.identifier.issn1939-4586
dc.identifier.urihttp://hdl.handle.net/1721.1/70512
dc.description.abstractThe respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC). Each phase is associated with the periodic expression of thousands of genes, producing oscillating patterns of gene-expression found in synchronized cultures and in single cells of slowly growing unsynchronized cultures. Systematic variation in the durations of the HOC and LOC phases can account quantitatively for well-studied transcriptional responses to growth rate differences. Here we show that a similar mechanism, transitions from the HOC phase to the LOC phase, can account for much of the common environmental stress response (ESR) and for the cross protection by a preliminary heat stress (or slow growth rate) to subsequent lethal heat-stress. Similar to the budding yeast metabolic cycle, we suggest that a metabolic cycle, coupled in a similar way to the ESR, in the distantly related fission yeast, Schizosaccharomyces pombe, and in human can explain gene-expression and respiratory patterns observed in these organisms. Although metabolic cycling is associated with the G0/G1 phase of the cell division cycle of slowly growing budding yeast, transcriptional cycling was detected in the G2 phase of the division cycle in fission yeast, consistent with the idea that respiratory metabolic cycling occurs during the phases of the cell division cycle associated with mass accumulation in these divergent eukaryotes.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (GM046406)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.). Pioneer Award (1DP1OD003936)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (ECCS 0835623)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (GM096193)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (U54CA143874)en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.). Center for Quantitative Biology (GM071508)en_US
dc.language.isoen_US
dc.publisherAmerican Society for Cell Biologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1091/mbc.E11-11-0961en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceAmerican Society for Cell Biologyen_US
dc.titleA Conserved Cell Growth Cycle Can Account for the Environmental Stress Responses of Divergent Eukaryotesen_US
dc.typeArticleen_US
dc.identifier.citationSlavov, N. et al. “A Conserved Cell Growth Cycle Can Account for the Environmental Stress Responses of Divergent Eukaryotes.” Molecular Biology of the Cell (2012): Web. 4 May 2012.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Materials Processing Centeren_US
dc.contributor.departmentMassachusetts Institute of Technology. Materials Processing Centeren_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.approvervan Oudenaarden, Alexander
dc.contributor.mitauthorSlavov, Nikolai G.
dc.contributor.mitauthorvan Oudenaarden, Alexander
dc.contributor.mitauthorBotstein, David
dc.relation.journalMolecular Biology of the Cellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSlavov, N.; Airoldi, E.; van Oudenaarden, A.; Botstein, D.en
dc.identifier.orcidhttps://orcid.org/0000-0003-2035-1820
mit.licensePUBLISHER_POLICYen_US


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