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Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain

Research and Teaching Output of the MIT Community

Show simple item record Scott, Benjamin B. Gardner, Timothy Ji, Ni Fee, Michale S. Lois, Carlos 2012-07-24T13:46:19Z 2012-07-24T13:46:19Z 2012-01 2011-11
dc.identifier.issn 0270-6474
dc.identifier.issn 1529-2401
dc.description.abstract Most non-mammalian vertebrate species add new neurons to existing brain circuits throughout life, a process thought to be essential for tissue maintenance, repair, and learning. How these new neurons migrate through the mature brain and which cues trigger their integration within a functioning circuit is not known. To address these questions, we used two-photon microscopy to image the addition of genetically labeled newly generated neurons into the brain of juvenile zebra finches. Time-lapse in vivo imaging revealed that the majority of migratory new neurons exhibited a multipolar morphology and moved in a nonlinear manner for hundreds of micrometers. Young neurons did not use radial glia or blood vessels as a migratory scaffold; instead, cells extended several motile processes in different directions and moved by somal translocation along an existing process. Neurons were observed migrating for ∼2 weeks after labeling injection. New neurons were observed to integrate in close proximity to the soma of mature neurons, a behavior that may explain the emergence of clusters of neuronal cell bodies in the adult songbird brain. These results provide direct, in vivo evidence for a wandering form of neuronal migration involved in the addition of new neurons in the postnatal brain. en_US
dc.language.iso en_US
dc.publisher Society for Neuroscience en_US
dc.relation.isversionof en_US
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. en_US
dc.source SFN en_US
dc.title Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain en_US
dc.type Article en_US
dc.identifier.citation Scott, B. Benjamin et al. "Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain" The Journal of Neuroscience, January 25, 2012 32(4):1436–1446. en_US
dc.contributor.department Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences en_US
dc.contributor.department McGovern Institute for Brain Research at MIT en_US
dc.contributor.approver Fee, Michale S.
dc.contributor.mitauthor Gardner, Timothy
dc.contributor.mitauthor Fee, Michale S.
dc.relation.journal Journal of Neuroscience en_US
dc.identifier.mitlicense PUBLISHER_POLICY en_US
dc.eprint.version Final published version en_US
dc.type.uri en_US
eprint.status en_US
dspace.orderedauthors Scott, Benjamin B.; Gardner, Timothy; Ji, Ni; Fee, Michale S.; Lois, Carlos en_US

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