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dc.contributor.authorAguirre, Aaron Dominic
dc.contributor.authorSawinski, Juergen
dc.contributor.authorHuang, Shu-Wei
dc.contributor.authorZhou, Chao
dc.contributor.authorDenk, Winfried
dc.contributor.authorFujimoto, James G.
dc.date.accessioned2012-08-01T16:52:32Z
dc.date.available2012-08-01T16:52:32Z
dc.date.issued2010-02
dc.date.submitted2010-02
dc.identifier.issn1094-4087
dc.identifier.urihttp://hdl.handle.net/1721.1/71933
dc.description.abstractOptical coherence microscopy (OCM) is a promising technique for high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging was developed at 1060 nm wavelength at frame rates up to 5 Hz with resolutions of < 4 µm axial and < 2 µm transverse. The system utilized a novel polarization compensation method to combat wavelength dependent source polarization and achieve broadband electro-optic phase modulation compatible with ultrahigh axial resolution. In addition, the system incorporated an auto-focusing feature that enables precise, near real-time alignment of the confocal and coherence gates in tissue, allowing user-friendly optimization of image quality during the imaging procedure. Ex vivo cellular images of human esophagus, colon, and cervix as well as in vivo results from human skin are presented. Finally, the system design is demonstrated with a miniaturized piezoelectric fiber-scanning probe which can be adapted for laparoscopic and endoscopic imaging applications.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (R01-CA75289-13)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) R01-EY11289-25en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (FA9550-07-1-0101)en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (FA9550-07-1-0014)en_US
dc.description.sponsorshipMax Planck Society for the Advancement of Scienceen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Fellowship) (F31 EB005978)en_US
dc.language.isoen_US
dc.publisherOptical Society of Americaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1364/OE.18.004222en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePubMed Centralen_US
dc.titleHigh speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probeen_US
dc.typeArticleen_US
dc.identifier.citationAguirre, Aaron D. et al. “High Speed Optical Coherence Microscopy with Autofocus Adjustment and a Miniaturized Endoscopic Imaging Probe.” Optics Express 18.5 (2010): 4222.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.approverFujimoto, James G.
dc.contributor.mitauthorAguirre, Aaron Dominic
dc.contributor.mitauthorHuang, Shu-Wei
dc.contributor.mitauthorZhou, Chao
dc.contributor.mitauthorFujimoto, James G.
dc.relation.journalOptics Expressen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsAguirre, Aaron D.; Sawinski, Juergen; Huang, Shu-Wei; Zhou, Chao; Denk, Winfried; Fujimoto, James G.en
dc.identifier.orcidhttps://orcid.org/0000-0002-0828-4357
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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