Show simple item record

dc.contributor.authorWong, Sze Yinn
dc.contributor.authorMoskowitz, Joshua Seth
dc.contributor.authorVeselinovic, Jovana
dc.contributor.authorRosario, Ryan A.
dc.contributor.authorTimachova, Ksenia
dc.contributor.authorBlaisse, Michael R.
dc.contributor.authorFuller, Renee C.
dc.contributor.authorKlibanov, Alexander M.
dc.contributor.authorHammond, Paula T
dc.date.accessioned2012-08-01T18:14:45Z
dc.date.available2012-08-01T18:14:45Z
dc.date.issued2010-11
dc.date.submitted2010-07
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.urihttp://hdl.handle.net/1721.1/71936
dc.description.abstractHere we present a new bifunctional layer-by-layer (LbL) construct made by combining a permanent microbicidal polyelectrolyte multilayered (PEM) base film with a hydrolytically degradable PEM top film that offers controlled and localized delivery of therapeutics. Two degradable film architectures are presented: (1) bolus release of an antibiotic (gentamicin) to eradicate initial infection at the implant site, or (2) sustained delivery of an anti-inflammatory drug (diclofenac) to cope with inflammation at the site of implantation due to tissue injury. Each degradable film was built on top of a permanent base film that imparts the implantable device surface with microbicidal functionality that prevents the formation of biofilms. Controlled-delivery of gentamicin was demonstrated over hours and that of diclofenac over days. Both drugs retained their efficacy upon release. The permanent microbicidal base film was biocompatible with A549 epithelial cancer cells and MC3T3-E1 osteoprogenitor cells, while also preventing bacteria attachment from turbid media for the entire duration of the two weeks studied. The microbicidal base film retains its functionality after the biodegradable films have completely degraded. The versatility of these PEM films and their ability to prevent biofilm formation make them attractive as coatings for implantable devices.en_US
dc.description.sponsorshipUnited States. Army Research Office. Institute for Soldier Nanotechnologiesen_US
dc.description.sponsorshipNational Institutes of Health (U.S.)en_US
dc.description.sponsorshipNational Institute on Aging (5R01AG029601-03)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ja106288cen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleDual Functional Polyelectrolyte Multilayer Coatings for Implants: Permanent Microbicidal Base with Controlled Release of Therapeutic Agentsen_US
dc.typeArticleen_US
dc.identifier.citationWong, Sze Yinn et al. “Dual Functional Polyelectrolyte Multilayer Coatings for Implants: Permanent Microbicidal Base with Controlled Release of Therapeutic Agents.” Journal of the American Chemical Society 132.50 (2010): 17840–17848.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Soldier Nanotechnologiesen_US
dc.contributor.departmentHarvard University--MIT Division of Health Sciences and Technologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemical Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.approverKlibanov, Alexander M.
dc.contributor.mitauthorWong, Sze Yinn
dc.contributor.mitauthorMoskowitz, Joshua Seth
dc.contributor.mitauthorVeselinovic, Jovana
dc.contributor.mitauthorRosario, Ryan A.
dc.contributor.mitauthorTimachova, Ksenia
dc.contributor.mitauthorBlaisse, Michael R.
dc.contributor.mitauthorFuller, Renee C.
dc.contributor.mitauthorKlibanov, Alexander M.
dc.contributor.mitauthorHammond, Paula T.
dc.relation.journalJournal of the American Chemical Societyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsWong, Sze Yinn; Moskowitz, Joshua S.; Veselinovic, Jovana; Rosario, Ryan A.; Timachova, Ksenia; Blaisse, Michael R.; Fuller, Renée C.; Klibanov, Alexander M.; Hammond, Paula T.en
dc.identifier.orcidhttps://orcid.org/0000-0003-3830-714X
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record