dc.contributor.author | Maimone, Thomas | |
dc.contributor.author | Buchwald, Stephen Leffler | |
dc.date.accessioned | 2012-08-27T16:08:09Z | |
dc.date.available | 2012-08-27T16:08:09Z | |
dc.date.issued | 2010-07 | |
dc.date.submitted | 2010-05 | |
dc.identifier.issn | 0002-7863 | |
dc.identifier.issn | 1520-5126 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/72344 | |
dc.description.abstract | An efficient Pd catalyst for the O-arylation of ethyl acetohydroximate with aryl chlorides, bromides, and iodides has been developed. Ethyl acetohydroximate serves as an efficient hydroxylamine equivalent for C−O cross-coupling, thereby allowing for the preparation of O-arylhydroxylamines from simple aryl halides. Short reaction times and broad substrate scope, including heteroaryl coupling partners, allow access to O-arylhydroxylamines that would be difficult to prepare in a single step by traditional methods. Moreover, the O-arylated products so formed can be directly transformed into substituted benzofurans in a single operation. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant Number GM-58160) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) Postdoctoral Fellowship (1F32GM088931) | en_US |
dc.language.iso | en_US | |
dc.publisher | American Chemical Society (ACS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1021/ja1044874 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | PMC | en_US |
dc.title | Pd-Catalyzed O-Arylation of Ethyl Acetohydroximate: Synthesis of O-Arylhydroxylamines and Substituted Benzofurans | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Maimone, Thomas J., and Stephen L. Buchwald. “Pd-Catalyzed O-Arylation of Ethyl Acetohydroximate: Synthesis of O-Arylhydroxylamines and Substituted Benzofurans.” Journal of the American Chemical Society 132.29 (2010): 9990–9991. | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
dc.contributor.approver | Buchwald, Stephen L. | |
dc.contributor.mitauthor | Maimone, Thomas | |
dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
dc.relation.journal | Journal of the American Chemical Society | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Maimone, Thomas J.; Buchwald, Stephen L. | en |
dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
mit.license | PUBLISHER_POLICY | en_US |
mit.metadata.status | Complete | |