Show simple item record

dc.contributor.authorNam, Jin-Wu
dc.contributor.authorBartel, David
dc.date.accessioned2012-08-30T14:37:02Z
dc.date.available2012-08-30T14:37:02Z
dc.date.issued2012-06
dc.date.submitted2012-03
dc.identifier.issn1088-9051
dc.identifier.issn1088-9051
dc.identifier.urihttp://hdl.handle.net/1721.1/72451
dc.description.abstractThousands of long non-coding RNAs (lncRNAs) have been found in vertebrate animals, a few of which have known biological roles. To better understand the genomics and features of lncRNAs in invertebrates, we used available RNA-seq, poly(A)-site, and ribosome-mapping data to identify lncRNAs of C. elegans. We found 170 long intervening ncRNAs (lincRNAs), which had single- or multi-exonic structures that did not overlap protein-coding transcripts, and about sixty antisense lncRNAs (ancRNAs), which were complementary to protein-coding transcripts. Compared to protein-coding genes, the lncRNA genes tended to be expressed in stage-dependent manner. Approximately 25% of the newly identified lincRNAs showed little signal for sequence conservation and mapped antisense to clusters of endogenous siRNAs, as would be expected if they serve as templates and targets for these siRNAs. The other 75% tended to be more conserved and included lincRNAs with intriguing expression and sequence features associating them with processes such as dauer formation, male identity, sperm formation, and interaction with sperm-specific mRNAs. Our study provides a glimpse into the lncRNA content of a non-vertebrate animal and a resource for future studies of lncRNA function.en_US
dc.language.isoen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionofhttp://dx.doi.org/10.1101/gr.140475.112en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceMIT web domainen_US
dc.titleLong non-coding RNAs in C. elegansen_US
dc.typeArticleen_US
dc.identifier.citationNam, J.-W., and D. Bartel. “Long Non-coding RNAs in C. Elegans.” Genome Research (2012).en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.approverBartel, David
dc.contributor.mitauthorNam, Jin-Wu
dc.contributor.mitauthorBartel, David
dc.relation.journalGenome Researchen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsNam, J.-W.; Bartel, D.en
dc.identifier.orcidhttps://orcid.org/0000-0002-3872-2856
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record