Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography
Author(s)Srinivasan, Vivek J.; Sakadžic, Sava; Gorczynska, Iwona; Ruvinskaya, Svetlana; Wu, Weicheng; Fujimoto, James G.; Boas, David A.; ... Show more Show less
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We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.
DepartmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Optical Society of America
Srinivasan, Vivek J. et al. “Depth-resolved Microscopy of Cortical Hemodynamics with Optical Coherence Tomography.” Optics Letters 34.20 (2009): 3086.
Author's final manuscript