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dc.contributor.authorKahn, Itamar
dc.contributor.authorDesai, Mitul
dc.contributor.authorKnoblich, Ulf
dc.contributor.authorBernstein, Jacob G.
dc.contributor.authorHenninger, Michael Alan
dc.contributor.authorGraybiel, Ann M.
dc.contributor.authorBoyden, Edward Stuart
dc.contributor.authorBuckner, Randy L.
dc.contributor.authorMoore, Christopher I.
dc.date.accessioned2012-09-20T12:55:48Z
dc.date.available2012-09-20T12:55:48Z
dc.date.issued2011-10
dc.date.submitted2011-08
dc.identifier.issn0270-6474
dc.identifier.issn1529-2401
dc.identifier.urihttp://hdl.handle.net/1721.1/73059
dc.description.abstractThe blood oxygenation level-dependent (BOLD) signal serves as the basis for human functional MRI (fMRI). Knowledge of the properties of the BOLD signal, such as how linear its response is to sensory stimuli, is essential for the design and interpretation of fMRI experiments. Here, we combined the cell-type and site-specific causal control provided by optogenetics and fMRI (opto-fMRI) in mice to test the linearity of BOLD signals driven by locally induced excitatory activity. We employed high-resolution mouse fMRI at 9.4 tesla to measure the BOLD response, and extracellular electrophysiological recordings to measure the effects of stimulation on single unit, multiunit, and local field potential activity. Optically driven stimulation of layer V neocortical pyramidal neurons resulted in a positive local BOLD response at the stimulated site. Consistent with a linear transform model, this locally driven BOLD response summated in response to closely spaced trains of stimulation. These properties were equivalent to responses generated through the multisynaptic method of driving neocortical activity by tactile sensory stimulation, and paralleled changes in electrophysiological measures. These results illustrate the potential of the opto-fMRI method and reinforce the critical assumption of human functional neuroimaging that—to first approximation—the BOLD response tracks local neural activity levels.en_US
dc.language.isoen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1523/jneurosci.0007-11.2011en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceSFNen_US
dc.titleCharacterization of the Functional MRI Response Temporal Linearity via Optical Control of Neocortical Pyramidal Neuronsen_US
dc.typeArticleen_US
dc.identifier.citationKahn, I. et al. “Characterization of the Functional MRI Response Temporal Linearity via Optical Control of Neocortical Pyramidal Neurons.” Journal of Neuroscience 31.42 (2011): 15086–15091.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Synthetic Neurobiology Groupen_US
dc.contributor.departmentdeleteen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Physicsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Media Laboratoryen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.departmentProgram in Media Arts and Sciences (Massachusetts Institute of Technology)en_US
dc.contributor.mitauthorDesai, Mitul
dc.contributor.mitauthorKnoblich, Ulf
dc.contributor.mitauthorBernstein, Jacob G.
dc.contributor.mitauthorHenninger, Michael Alan
dc.contributor.mitauthorGraybiel, Ann M.
dc.contributor.mitauthorBoyden, Edward Stuart
dc.contributor.mitauthorMoore, Christopher I.
dc.relation.journalJournal of Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsKahn, I.; Desai, M.; Knoblich, U.; Bernstein, J.; Henninger, M.; Graybiel, A. M.; Boyden, E. S.; Buckner, R. L.; Moore, C. I.en
dc.identifier.orcidhttps://orcid.org/0000-0002-5680-2630
dc.identifier.orcidhttps://orcid.org/0000-0002-7472-5480
dc.identifier.orcidhttps://orcid.org/0000-0002-0419-3351
dc.identifier.orcidhttps://orcid.org/0000-0002-8381-7555
dc.identifier.orcidhttps://orcid.org/0000-0002-0756-5587
dc.identifier.orcidhttps://orcid.org/0000-0002-4326-7720
dspace.mitauthor.errortrue
mit.licensePUBLISHER_POLICYen_US


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