Show simple item record

Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots using Tetrazine-Norbornene Cycloaddition

dc.contributor.authorHan, Hee-Sun
dc.contributor.authorDevaraj, Neal K.
dc.contributor.authorLee, Jungmin
dc.contributor.authorHilderbrand, Scott A.
dc.contributor.authorWeissleder, Ralph
dc.contributor.authorBawendi, Moungi G.
dc.date.accessioned2012-09-20T15:50:17Z
dc.date.available2012-09-20T15:50:17Z
dc.date.issued2010-05
dc.date.submitted2010-02
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.urihttp://hdl.handle.net/1721.1/73064
dc.description.abstractWe present a bioorthogonal and modular conjugation method for efficient coupling of organic dyes and biomolecules to quantum dots (QDs) using a norbornene−tetrazine cycloaddition. The use of noncoordinating functional groups combined with the rapid rate of the cycloaddition leads to highly efficient conjugation. We have applied this method to the in situ targeting of norbornene-coated QDs to live cancer cells labeled with tetrazine-modified proteins.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH Grant 5-U54-CA119349-05)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH Grant 5R01CA126642-02)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH Grant U01-HL080731)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH Grant T32-CA79443)en_US
dc.language.isoen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/ja101677ren_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titleDevelopment of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots using Tetrazine-Norbornene Cycloadditionen_US
dc.typeArticleen_US
dc.identifier.citationHan, Hee-Sun et al. “Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots Using Tetrazine−Norbornene Cycloaddition.” Journal of the American Chemical Society 132.23 (2010): 7838–7839. Web.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorBawendi, Moungi G.
dc.contributor.mitauthorHan, Hee-Sun
dc.contributor.mitauthorDevaraj, Neal K.
dc.contributor.mitauthorLee, Jungmin
dc.contributor.mitauthorHilderbrand, Scott A.
dc.contributor.mitauthorWeissleder, Ralph
dc.relation.journalJournal of the American Chemical Societyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsHan, Hee-Sun; Devaraj, Neal K.; Lee, Jungmin; Hilderbrand, Scott A.; Weissleder, Ralph; Bawendi, Moungi G.en
dc.identifier.orcidhttps://orcid.org/0000-0003-0828-4143
dc.identifier.orcidhttps://orcid.org/0000-0003-2220-4365
mit.licensePUBLISHER_POLICYen_US
mit.metadata.statusComplete


Files in this item

Thumbnail
Name:
Bawendi_Development of.pdf
Size:
771.2Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record