Show simple item record

dc.contributor.authorPinheiro, Elaine M.
dc.contributor.authorXie, Zhigang
dc.contributor.authorNorovich, Amy L.
dc.contributor.authorVidaki, Marina
dc.contributor.authorTsai, Li-Huei
dc.contributor.authorGertler, Frank
dc.date.accessioned2012-10-02T12:27:27Z
dc.date.available2012-10-02T12:27:27Z
dc.date.issued2011-07
dc.date.submitted2010-10
dc.identifier.issn1465-7392
dc.identifier.issn1476-4679
dc.identifier.urihttp://hdl.handle.net/1721.1/73532
dc.description.abstractDuring corticogenesis, pyramidal neurons (~80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia[superscript 1], [superscript 2], and then migrate to their proper position within the cortex[superscript 1], [superscript 3]. As pyramidal neurons migrate radially, they remain attached to their glial substrate as they pass through the subventricular and intermediate zones, regions rich in tangentially migrating interneurons and axon fibre tracts. We examined the role of lamellipodin (Lpd), a homologue of a key regulator of neuronal migration and polarization in Caenorhabditis elegans, in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate. Mechanistically, Lpd depletion reduced the activity of SRF, a transcription factor regulated by changes in the ratio of polymerized to unpolymerized actin. Therefore, Lpd depletion exposes a role for SRF in directing pyramidal neurons to select a radial migration pathway along glia rather than a tangential migration mode.en_US
dc.description.sponsorshipRuth L. Kirschstein National Research Service Award (Grant F32-GM074507)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant GM068678)en_US
dc.description.sponsorshipHoward Hughes Medical Institute (Investigator)en_US
dc.description.sponsorshipDavid H. Koch Institute for Integrative Cancer Research at MIT (Development Award)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/ncb2292en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.rights.urien_US
dc.sourcePMCen_US
dc.titleLpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neuronsen_US
dc.typeArticleen_US
dc.identifier.citationPinheiro, Elaine M. et al. “Lpd Depletion Reveals That SRF Specifies Radial Versus Tangential Migration of Pyramidal Neurons.” Nature Cell Biology 13.8 (2011): 989–995.en_US
dc.contributor.departmentmove to dc.description.sponsorshipen_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.mitauthorPinheiro, Elaine M.
dc.contributor.mitauthorNorovich, Amy L.
dc.contributor.mitauthorVidaki, Marina
dc.contributor.mitauthorTsai, Li-Huei
dc.contributor.mitauthorGertler, Frank
dc.relation.journalNature Cell Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsPinheiro, Elaine M.; Xie, Zhigang; Norovich, Amy L.; Vidaki, Marina; Tsai, Li-Huei; Gertler, Frank B.en
dc.identifier.orcidhttps://orcid.org/0000-0003-1262-0592
dc.identifier.orcidhttps://orcid.org/0000-0003-3214-4554
mit.licensePUBLISHER_POLICYen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record