Exploiting synthetic lethal interactions for targeted cancer therapy
Author(s)Reinhardt, H. Christian; Jiang, Hai; Hemann, Michael; Yaffe, Michael B.
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Emerging data suggests that synthetic lethal interactions between mutated oncogenes/tumor suppressor genes and molecules involved in DNA damage signaling and repair can be therapeutically exploited to preferentially kill tumor cells. In this review, we discuss the concept of synthetic lethality, and describe several recent examples in which this concept was successfully implemented to target tumor cells in culture, in mouse models, and in human cancer patients.
March 15, 2011
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology
Reinhardt, H. Christian et al. “Exploiting Synthetic Lethal Interactions for Targeted Cancer Therapy.” Cell Cycle 8.19 (2009): 3112–3119.
Author's final manuscript