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Discovering Regulatory Overlapping RNA Transcripts

dc.contributor.authorDanford, Timothy William
dc.contributor.authorDowell, Robin D.
dc.contributor.authorAgarwala, Sundeep
dc.contributor.authorGrisafi, Paula
dc.contributor.authorFink, Gerald R.
dc.contributor.authorGifford, David K.
dc.date.accessioned2012-10-09T17:25:47Z
dc.date.available2012-10-09T17:25:47Z
dc.date.issued2010-05
dc.date.submitted2010-04
dc.identifier.isbn978-3-642-12682-6
dc.identifier.issn0302-9743
dc.identifier.issn1611-3349
dc.identifier.urihttp://hdl.handle.net/1721.1/73688
dc.description.abstractSTEREO is a novel algorithm that discovers cis-regulatory RNA interactions by assembling complete and potentially overlapping same-strand RNA transcripts from tiling expression data. STEREO first identifies coherent segments of transcription and then discovers individual transcripts that are consistent with the observed segments given intensity and shape constraints. We used STEREO to identify 1446 regions of overlapping transcription in two strains of yeast, including transcripts that comprise a new form of molecular toggle switch that controls gene variegation.en_US
dc.language.isoen_US
dc.publisherSpringer Berlin/Heidelbergen_US
dc.relation.isversionofhttp://dx.doi.org/ 10.1007/978-3-642-12683-3_8en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourceMIT web domainen_US
dc.titleDiscovering Regulatory Overlapping RNA Transcriptsen_US
dc.typeArticleen_US
dc.identifier.citationDanford, Timothy et al. “Discovering Regulatory Overlapping RNA Transcripts.” Research in Computational Molecular Biology. Ed. Bonnie Berger. LNCS Vol. 6044. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. 110-122.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentWhitehead Institute for Biomedical Researchen_US
dc.contributor.mitauthorDanford, Timothy William
dc.contributor.mitauthorDowell, Robin D.
dc.contributor.mitauthorAgarwala, Sundeep
dc.contributor.mitauthorGrisafi, Paula
dc.contributor.mitauthorFink, Gerald R.
dc.contributor.mitauthorGifford, David K.
dc.relation.journalResearch in Computational Molecular Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/ConferencePaperen_US
dspace.orderedauthorsDanford, Timothy; Dowell, Robin; Agarwala, Sudeep; Grisafi, Paula; Fink, Gerald; Gifford, Daviden
dc.identifier.orcidhttps://orcid.org/0000-0001-7665-9985
dc.identifier.orcidhttps://orcid.org/0000-0003-3704-2899
dc.identifier.orcidhttps://orcid.org/0000-0003-1709-4034
dspace.mitauthor.errortrue
mit.licenseOPEN_ACCESS_POLICYen_US
mit.metadata.statusComplete


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