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Promiscuous binding of extracellular peptides to cell surface class I MHC protein

Author(s)
Eisen, Herman N.; Hou, Xun Helen; Shen, Chase; Wang, Kaidi; Tanguturi, Varsha Keelara; Smith, Crysela; Kozyrytska, Katerina; Nambiar, Lakshmi; McKinley, Carol A.; Chen, Jianzhu; Cohen, Richard J.; ... Show more Show less
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Abstract
Algorithms derived from measurements of short-peptide (8–10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K[superscript b], can bind well over 1 million different peptides with significant affinity (<500 nM), a level of ligand-binding promiscuity approaching the level of heat shock protein binding of unfolded proteins. MHC proteins can, nevertheless, discriminate between similar peptides and bind many of them with high (nanomolar) affinity. Some insights into this high-promiscuity/high-affinity behavior and its impact on immunodominant peptides in T-cell responses to some infections and vaccination are suggested by results obtained here from testing a model developed to predict the number of cell surface peptide–MHC complexes that form on cells exposed to extracellular (exogenous) peptides.
Date issued
2012-03
URI
http://hdl.handle.net/1721.1/74019
Department
Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Citation
Eisen, H. N. et al. “Promiscuous Binding of Extracellular Peptides to Cell Surface Class I MHC Protein.” Proceedings of the National Academy of Sciences 109.12 (2012): 4580–4585. ©2012 by the National Academy of Sciences
Version: Final published version
ISSN
0027-8424
1091-6490

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