| dc.contributor.author | Xie, Huangming | |
| dc.contributor.author | Sun, Lei | |
| dc.contributor.author | Lodish, Harvey F | |
| dc.date.accessioned | 2012-10-19T16:39:44Z | |
| dc.date.available | 2012-10-19T16:39:44Z | |
| dc.date.issued | 2009-10 | |
| dc.identifier.issn | 1744-7631 | |
| dc.identifier.issn | 1472-8222 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/74156 | |
| dc.description | Author Manuscript 2011 October 20. | en_US |
| dc.description.abstract | Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases such as type 2 diabetes, atherosclerosis, and certain types of cancer. Fundamental for the development of novel therapeutics for obesity and its associated metabolic syndromes is an understanding of the regulation of fat cell development. Recent computational and experimental studies have shown that microRNAs (miRNAs) play a role in metabolic tissue development, lipid metabolism and glucose homeostasis. In addition, many miRNAs are dysregulated in metabolic tissues from obese animals and humans, which potentially contributes to the pathogenesis of obesity-associated complications. In this review we summarize the current state of understanding of the roles of miRNAs in metabolic tissues under normal development and obese conditions, and discuss the potential use of miRNAs as therapeutic targets. | en_US |
| dc.description.sponsorship | Singapore-MIT Alliance (Grant DK047618) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant DK068348) | en_US |
| dc.language.iso | en_US | |
| dc.publisher | Informa Healthcare | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1517/14728220903190707 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike 3.0 | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Targeting microRNAs in obesity | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Xie, Huangming, Lei Sun, and Harvey F Lodish. “Targeting microRNAs in Obesity.” Expert Opinion on Therapeutic Targets 13.10 (2009): 1227–1238. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Sun, Lei | |
| dc.contributor.mitauthor | Lodish, Harvey F. | |
| dc.relation.journal | Expert Opinion on Therapeutic Targets | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dspace.orderedauthors | Xie, Huangming; Sun, Lei; Lodish, Harvey F | en |
| dc.identifier.orcid | https://orcid.org/0000-0002-7029-7415 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
| mit.metadata.status | Complete | |
