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dc.contributor.authorShapira, Sagi D.
dc.contributor.authorGat-Viks, Irit
dc.contributor.authorShum, Bennett O. V.
dc.contributor.authorDricot, Amelie
dc.contributor.authorDeGrace, Marciela M.
dc.contributor.authorWu, Liguo
dc.contributor.authorGupta, Piyush
dc.contributor.authorHao, Tong
dc.contributor.authorSilver, Serena J.
dc.contributor.authorRoot, David E.
dc.contributor.authorHill, David E.
dc.contributor.authorRegev, Aviv
dc.contributor.authorHacohen, Nir
dc.date.accessioned2012-10-30T16:37:49Z
dc.date.available2012-10-30T16:37:49Z
dc.date.issued2009-12
dc.date.submitted2009-12
dc.identifier.issn0092-8674
dc.identifier.issn1097-4172
dc.identifier.urihttp://hdl.handle.net/1721.1/74511
dc.descriptionavailable in PMC 2010 June 28.en_US
dc.description.abstractDuring the course of a viral infection, viral proteins interact with an array of host proteins and pathways. Here, we present a systematic strategy to elucidate the dynamic interactions between H1N1 influenza and its human host. A combination of yeast two-hybrid analysis and genome-wide expression profiling implicated hundreds of human factors in mediating viral-host interactions. These factors were then examined functionally through depletion analyses in primary lung cells. The resulting data point to potential roles for some unanticipated host and viral proteins in viral infection and the host response, including a network of RNA-binding proteins, components of WNT signaling, and viral polymerase subunits. This multilayered approach provides a comprehensive and unbiased physical and regulatory model of influenza-host interactions and demonstrates a general strategy for uncovering complex host-pathogen relationships.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant U01 AI074575)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant U54 AI057159)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH New Innovator Award)en_US
dc.description.sponsorshipFord Foundation (Predoctoral Fellowship)en_US
dc.description.sponsorshipEllison Medical Foundationen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (NIH grant R01 HG001715)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (grant P50 HG004233)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (PIONEER award)en_US
dc.description.sponsorshipHoward Hughes Medical Instituteen_US
dc.description.sponsorshipBurroughs Wellcome Fund (Career Award at the Scientific Interface)en_US
dc.description.sponsorshipAlfred P. Sloan Foundationen_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.cell.2009.12.018en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titleA physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infectionen_US
dc.typeArticleen_US
dc.identifier.citationShapira, Sagi D. et al. “A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection.” Cell 139.7 (2009): 1255–1267. Web.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorRegev, Aviv
dc.relation.journalCellen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsShapira, Sagi D.; Gat-Viks, Irit; Shum, Bennett O.V.; Dricot, Amelie; de Grace, Marciela M.; Wu, Liguo; Gupta, Piyush B.; Hao, Tong; Silver, Serena J.; Root, David E.; Hill, David E.; Regev, Aviv; Hacohen, Niren
dc.identifier.orcidhttps://orcid.org/0000-0001-8567-2049
mit.licenseOPEN_ACCESS_POLICYen_US


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