mTOR: from growth signal integration to cancer, diabetes and ageing
Author(s)Zoncu, Roberto; Efeyan, Alejo; Sabatini, David M.
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In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing.
Departmentmove to dc.description.sponsorship; Massachusetts Institute of Technology. Department of Biology; Whitehead Institute for Biomedical Research
Nature Reviews Molecular Cell Biology
Nature Publishing Group
Zoncu, Roberto, Alejo Efeyan, and David M. Sabatini. “mTOR: From Growth Signal Integration to Cancer, Diabetes and Ageing.” Nature Reviews Molecular Cell Biology 12.1 (2010): 21–35.
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