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dc.contributor.authorBrohawn, Stephen G.
dc.contributor.authorPartridge, James R.
dc.contributor.authorWhittle, James Richardson Ross
dc.contributor.authorSchwartz, Thomas
dc.date.accessioned2012-11-01T20:04:02Z
dc.date.available2012-11-01T20:04:02Z
dc.date.issued2009-07
dc.identifier.issn0969-2126
dc.identifier.issn1878-4186
dc.identifier.urihttp://hdl.handle.net/1721.1/74557
dc.description.abstractNuclear pore complexes (NPCs) perforate the nuclear envelope and represent the exclusive passageway into and out of the nucleus of the eukaryotic cell. Apart from their essential transport function, components of the NPC have important, direct roles in nuclear organization and in gene regulation. Because of its central role in cell biology, it is of considerable interest to determine the NPC structure at atomic resolution. The complexity of these large, 40–60 MDa protein assemblies has for decades limited such structural studies. More recently, exploiting the intrinsic modularity of the NPC, structural biologists are making progress toward understanding this nanomachine in molecular detail. Structures of building blocks of the stable, architectural scaffold of the NPC have been solved, and distinct models for their assembly proposed. Here we review the status of the field and lay out the challenges and the next steps toward a full understanding of the NPC at atomic resolution.en_US
dc.description.sponsorshipPew Charitable Trusts (Scholars Program)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant GM077537)en_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.str.2009.07.014en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alike 3.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en_US
dc.sourcePMCen_US
dc.titleThe nuclear pore complex has entered the atomic ageen_US
dc.typeArticleen_US
dc.identifier.citationBrohawn, Stephen G. et al. “The Nuclear Pore Complex Has Entered the Atomic Age.” Structure 17.9 (2009): 1156–1168.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorBrohawn, Stephen G.
dc.contributor.mitauthorPartridge, James R.
dc.contributor.mitauthorWhittle, James Richardson Ross
dc.contributor.mitauthorSchwartz, Thomas
dc.relation.journalStructureen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsBrohawn, Stephen G.; Partridge, James R.; Whittle, James R.R.; Schwartz, Thomas U.en
dc.identifier.orcidhttps://orcid.org/0000-0001-8012-1512
mit.licenseOPEN_ACCESS_POLICYen_US


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