Nanoparticles for targeting the infarcted heart

Author(s)
Dvir, Tal; Bauer, Michael; Schroeder, Avi; Tsui, Jonathan H.; Anderson, Daniel G.; ... Show more
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Abstract
We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.
Description
Author's Manuscript: 2012 October 12.
Date issued
2011-09
URI
http://hdl.handle.net/1721.1/75300
Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Dvir, Tal et al. “Nanoparticles Targeting the Infarcted Heart.” Nano Letters 11.10 (2011): 4411–4414.
Version: Author's final manuscript
ISSN
1530-6984
1530-6992
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